| 养阴清肺汤对大鼠肺纤维化的干预作用及对TGF-β1表达的影响 |
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| 引用本文： | 顾燕兰.养阴清肺汤对大鼠肺纤维化的干预作用及对TGF-β1表达的影响[J].江西中医学院学报,2011,23(5):61-62. |
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| 作者姓名： | 顾燕兰 |
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| 作者单位： | 苏州市中医医院 苏州 215000 |
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| 摘 要： | 目的:观察养阴清肺汤对博莱霉素(bleomycin,BLM)致大鼠肺纤维化模型的干预作用和转化生长因子-β1(transforminggrowth factorβ1,TGF-β1)的影响,探讨养阴清肺汤参与肺纤维化的机制。方法:健康SD大鼠60只随机分3组:正常对照组(生理盐水),模型组(博莱霉素),治疗组(博莱霉素+养阴清肺汤)。分别在第71,42,1,28天,每组5大鼠,HE染色观察支气管肺组织病理改变,免疫组化观察肺组织中TGF-β1表达。结果:(1)治疗组大鼠肺泡炎和肺纤维化发生率明显降低,且程度轻,无严重肺纤维化发生。(2)治疗组肺间质中TGF-β1表达比模型组明显减少(P<0.05)。结论:养阴清肺汤能减轻博莱霉素诱导的大鼠肺纤维化,可能是通过下调TGF-β1的表达而起作用。
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| 关 键 词： | 肺纤维化 养阴清肺汤 TGF-β1 |
Effect of Yangyinqingfei Decoction Inhibitor on Dleomycin -induced Pulmonary Fibrosis and its Mechanism in Rats |
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| GU Yan-lan.Effect of Yangyinqingfei Decoction Inhibitor on Dleomycin -induced Pulmonary Fibrosis and its Mechanism in Rats[J].Journal of Jiangxi College of Traditional Chinese Medicine,2011,23(5):61-62. |
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| Authors: | GU Yan-lan |
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| Institution: | GU Yan-lan Suzhou Municipal Hospital of traditional Chinese Medicine,215000 |
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| Abstract: | Objective: To study the effect of Yangyinqingfei decoction inhibitor on bleomycin-induced pulmonary fibrosis in rats and its possible mechanism.Methods: Sixty female were randomly divided into three groups: the model group,the control group and Yangyinqingfei decoction inhibitor treatment group,in which the rats were intratracheally instilled with bleomycin.From the first day after bleomycin challenge,by every day,treatment group was given daily Yangyinqingfei decoction,the other group were given sterile sa... |
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| Keywords: | Pulmonary fibrosis Yangyinqingfei decoction transforming growth factor-β（TGF-β1） |
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