Effectiveness of Nafcillin, Methicillin, and Cephalothin in Experimental Staphylococcus aureus Endocarditis |
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| Authors: | Jaime Carrizosa William D. Kobasa Donald Kaye |
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| Affiliation: | 1Department of Medicine, the Medical College of Pennsylvania, Philadelphia, Pennsylvania 19129 |
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| Abstract: | Nafcillin, methicillin, and cephalothin (40 mg/kg every 6 h) were all effective in reducing the number of Staphylococcus aureus in vegetations in rabbits with endocarditis. Nafcillin and methicillin reduced the number of S. aureus at a significantly faster rate than did cephalothin. Nafcillin and methicillin also reduced titers of the S. aureus more rapidly than did cephalothin in vitro, both in broth and in rabbit serum. |
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