| 肾脏纤维化与间充质转分化 |
| |
| 引用本文： | 封怡多,张东亮,刘文虎. 肾脏纤维化与间充质转分化[J]. 中国全科医学, 2012, 15(21): 2373-2374,2383 |
| |
| 作者姓名： | 封怡多 张东亮 刘文虎 |
| |
| 作者单位： | 首都医科大学附属北京友谊医院肾内科,首都医科大学肾病学系,北京市,100050 |
| |
| 摘 要： | 肾小管上皮间充质转分化(EMT)在肾脏纤维化进程中发挥着重要作用。新近研究表明,内皮细胞和足细胞也可发生间充质转分化,导致肾小球硬化以及蛋白尿。多种信号转导途径参与调节EMT,其中转化生长因子β(TGF-β)/Smad信号通路发挥核心作用。阻断TGF-β/Smad等信号通路,或应用内源性抗纤维化蛋白可抑制EMT,减轻肾脏纤维化。
|
| 关 键 词： | 细胞转分化 肾脏病学 纤维化 转化生长因子 |
Renal Fibrosis and Epithelial-Mesenchymal Transition |
| |
| FENG Yi-duo , ZHANG Dong-liang , LIU Wen-hu. Renal Fibrosis and Epithelial-Mesenchymal Transition[J]. Chinese General Practice, 2012, 15(21): 2373-2374,2383 |
| |
| Authors: | FENG Yi-duo ZHANG Dong-liang LIU Wen-hu |
| |
| Affiliation: | .Department of Nephrology,Beijing Friendship Hospital Affiliated to Capital Medical University,Faculty of Kidney Diseases of Capital Medical University,Beijing 100050,China |
| |
| Abstract: | Epithelial-mesenchymal transition(EMT)plays an important role in the process of kidney fibrosis.Recent studies indicate that endothelial cells and glomerular podocytes may also undergo transition,leading to glomerular sclerosis and proteinuria.Several intracellular signal transduction pathways involve in regulating EMT,and transforming growth factor beta(TGF-β)/Smad signaling pathway plays a control role.Blocking up TGF-β/Smad signaling pathways or use of endogenous antifibrotic protein can inhibit EMT and reduce renal fibrosis. |
| |
| Keywords: | Cell transdifferentiation Nephrolo Fibrosis Transforming growth factors |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
