Potentiated 5-hydroxytryptophan induced response suppression in rats following chronic reserpine |
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| Authors: | K L Brugge J N Hingtgen M H Aprison |
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| Affiliation: | 1. Department of Agronomy, University of Agriculture, Faisalabad 38040, Pakistan;2. The UWA Institute of Agriculture, The University of Western Australia, LB 5005 Perth, WA 6001, Australia;3. College of Food and Agricultural Sciences, King Saud University, Riyadh 11451, Saudi Arabia;4. Department of Botany, University of Agriculture, Faisalabad 38040, Pakistan;1. School of Hospitality Management, Zhejiang Yuexiu University, PR China;2. School of Economics and Management Dalian University of Technology, Dalian, PR China;3. Department of Business Administration ILMA University Karachi, Pakistan;4. Department of Occupational Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, 50200, Thailand;5. Faculty of Law, Binh Duong University, Viet Nam;6. Department of Quantity Surveying Faculty of Built Environment University of Malaya, 50603, Kuala Lumpur, Malaysia;1. Centre of Excellence in Molecular Biology, 87-West Canal Bank Road, University of Punjab, Lahore, Pakistan;2. Department of Genetics, Hazara University, Mansehra, KPK, Pakistan;3. School of Biological Sciences, University of the Punjab, Lahore, Pakistan;1. Department of Electrical and Computer Engineering, Old Dominion University, Norfolk, VA 23529, USA;2. Department of Computer Science, Tennessee State University, Nashville, TN 37209, USA;1. School of Business and Economics, University Putra Malaysia, Selangor, 43400, Malaysia;2. School of Economics and Management, Xinjiang University, Urumqi, 830047, China;3. Center for Innovation Management, Xinjiang University, Urumqi, 830047, China |
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| Abstract: | Since reserpine precipitates depression in some hypertensive patients, we tested this drug on our animal model of depression. The present experiment was designed to measure the effects of chronic reserpine treatment on 5-hydroxytryptophan (5-HTP) induced behavioral depression in rats trained on a food reinforcement operant schedule. Based on the Aprison et al. model of depression involving the serotonergic system, we predicted the development of receptor supersensitivity of postsynaptic serotonin (5-HT) receptors due to the decreased release of this neurotransmitter as a consequence of chronic reserpine treatment. Rats were trained on a VI 1 reinforcement schedule and then divided into 3 chronic treatment groups. One received daily injections of a placebo, another 0.025 mg/kg reserpine and the third 0.05 mg/kg reserpine. We found that 5-HTP induced behavioral depression was potentiated in rats chronically treated with reserpine, thus suggesting the development of supersensitive 5-HT receptors. These results support the hypothesis that in some types of human depression a decreased release of 5-HT occurs of sufficient duration to permit the subsequent development of supersensitive 5-HT receptors. |
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