| 阴茎勃起神经再生模型和机制的研究 |
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| 引用本文： | 林桂亭,Tom F Lue,Ching-Shwun Lin.阴茎勃起神经再生模型和机制的研究[J].中华男科学杂志,2007,13(12):1059-1063. |
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| 作者姓名： | 林桂亭 Tom F Lue Ching-Shwun Lin |
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| 作者单位： | 林桂亭（Department of Urology,University of California,San Francisco,CA 94143,USA） |
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| 基金项目： | 美国国立卫生研究院(NIH)重点课题 |
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| 摘 要： | 探明神经性勃起功能障碍(NED)的分子生物学机制以期对该类疾病进行神经调控干预,是男科学研究的当务之急。本文回顾了急性神经损伤、前列腺癌、糖尿病和帕金森病所致的NED的研究进展。通过利用大鼠阴茎勃起神经的盆腔大神经节(MPG),在体外构建一个三维培养体系来研究各种生长因子和细胞信号通路对神经再生的影响。体外结果表明脑源性神经生长因子(BDNF)通过JAK/STAT信号通路可显著促进NED的恢复,并在体内证实了该效应。因此,通过调控JAK/STAT信号通路来达到神经调控干预措施预防治疗神经性勃起功能障碍成为可能。
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| 关 键 词： | 神经性勃起功能障碍 盆腔大神经节 BDNF JAK/STAT信号通路 |
| 文章编号： | 1009-3591(2007)12-1059-05 |
| 修稿时间： | 2007年11月21 |
The in vitro and in vivo Experimental Models of Erectile Nerve Regeneration |
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| Gui-Ting Lin,Tom F Lue,Ching-Shwun Lin.The in vitro and in vivo Experimental Models of Erectile Nerve Regeneration[J].National Journal of Andrology,2007,13(12):1059-1063. |
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| Authors: | Gui-Ting Lin Tom F Lue Ching-Shwun Lin |
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| Institution: | Department of Urology,University of California,San Francisco,CA 94143,USA |
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| Abstract: | Neurogenic erectile dysfunction (NED) caused by pelvic floor surgeries/radiation therapies and associated with Parkinsons disease and diabetes remains a challenging healthcare issue. To facilitate NED research we have developed in vitro and in vivo experimental models. The in vitro model comprises the isolation, culture and treatment of rat major pelvic ganglia (MPG), which then produce outgrowing neurites whose length and molecular composition are indicative of the neurotrophic effect of the treatment agent. Through this approach we have confirmed that the brain-derived neurotrophic factor (BDNF) promotes nerve regeneration by activating the JAK/STAT signaling pathway. This has been further established by our in vivo model, which involves the transection or cruch of cavernous nerves and treatment with BDNF. |
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| Keywords: | BDNF |
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