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Action of vitamin D metabolites on PTH secretion in man |
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| Authors: | L. Miravet J. Guéris J. Redel A. Norman A. Ryckewaert |
| Affiliation: | 1. Unité de Recherches sur le Métabolisme Phosphocalcique, U.18 et Clinique Rhumatologique de l'H?pital Lariboisière, 75010, Paris, France 2. Centre de Recherches sur les Maladies Ostéoarticulaires, U.5 INSERM-ERA CNRS, H?pital Cochin, Paris, France 3. Department of Biochemistry, University of California, 92521, Riverside, California, USA |
| Abstract: | Summary We have examined the effects of metabolites of vitamin D [25OHD3, 1,25(OH)2D3, 24,25(OH)2D3, and 25,26(OH)2D3] on serum calcium and iPTH in human deficient-D osteomalacia. The four metabolites decreased iPTH, but only for 1,25(OH)2D3 was a significant correlation between increase of serum calcium and decrease of iPTH observed. The 24,25(OH)2D3 and 25,26(OH)2D3 decreased iPTH despite a decrease of serum calcium at the beginning of treatment. The 25OHD decreased iPTH before increased serum calcium. These results could be interpreted as a direct effect of metabolites of vitamin D on PTH secretion. However, the conversion of other metabolites and the calcium concentration in parathyroid cells must be determined before this hypothesis can be accepted. |
| Keywords: | 25-Hydroxycholecalciferol 1,25 Dihydroxycholecalciferol 24,25-Dihydroxycholecalciferol 25,26-Dihydroxycholecalciferol |
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