Expression of heat shock protein (Hsp) 70 and Hsp 40 in gastric cancer |
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Authors: | Isomoto Hajime Oka Mikio Yano Yoshitsugu Kanazawa Yusei Soda Hiroshi Terada Ryusuke Yasutake Toru Nakayama Toshiyuki Shikuwa Saburo Takeshima Fuminao Udono Heiichiro Murata Ikuo Ohtsuka Kenzo Kohno Shigeru |
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Affiliation: | Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan. hhisomot@net.nagasaki-u.ac.jp |
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Abstract: | Heat shock proteins (Hsp) 70 and Hsp 40 are stress proteins that cooperate as chaperones in mammalian cells. We determined the expression of Hsp 70 and Hsp 40 in 81 gastric cancers. Immunoreactivities to Hsp 70 and Hsp 40 were detected in 67.9 and 22.2% of tumors, respectively. Immunohistochemical analysis showed enhanced Hsp 70 and Hsp 40 expression in gastric tumor tissue, relative to the surrounding normal tissue. Overexpression of Hsp 70 and Hsp 40 was also confirmed by immunoblotting. Among various clinicopathological parameters, low histopathological differentiation was associated with reduced expression of both proteins. |
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