| Ca~(2 )对窦房结内不同类型起搏细胞动作电位的影响 |
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| 引用本文： | 顾炎平,叶定忠,张小慧,朱思明,葛志恒.Ca~(2 )对窦房结内不同类型起搏细胞动作电位的影响[J].南京医科大学学报,1986(2). |
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| 作者姓名： | 顾炎平 叶定忠 张小慧 朱思明 葛志恒 |
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| 作者单位： | 南京医学院生理学研究室
(顾炎平，叶定忠，张小慧，朱思明)，南京医学院生理学研究室(葛志恒) |
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| 摘 要： | 在23份离体兔心窦房标本上观察了细胞外钙离子(Ca~(2 )]_0)对窦房结起搏细胞动作电位的影响,发现随Ca~(2 )]_0的增加,优势起搏细胞的动作电位幅度(APA)、最大舒张期电位(MDP)、0相最大余极速率(MRD)降低,舒张期余极速率(RDD)增高,起始电位(TP)上移,4相向0相的过渡更加圆滑,动作电位时程(APD)延长。而潜在起搏细胞的APA、MDP、MRD增高,RDD降低,TP下移,APD缩短。上述结果提示,窦房结内不同类型起搏细胞对Ca~(2 )的反应存在差异。
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| 关 键 词： | 窦房结/生理学 Ca~(2 )/生理学 离子通道/生理学 起搏细胞 动作电位 动物 兔 体外研究 |
THE EFFECTS OF CALCIUM ON THE ACTION POTENTIAL OF DIFFERENT TYPES OF THE PACEMAKER CELLS IN THE SINOATRIAL NODE |
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| Gu Yanping.THE EFFECTS OF CALCIUM ON THE ACTION POTENTIAL OF DIFFERENT TYPES OF THE PACEMAKER CELLS IN THE SINOATRIAL NODE[J].Acta Universitatis Medicinalis Nanjing,1986(2). |
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| Authors: | Gu Yanping |
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| Abstract: | The effects of calcium on differenttypes of the pacemaker cells were inves-tigated in 23 isolated rabbit sinus nodalpreperations by the microelectrode tech-nique. A rise in the concentration ofcalcium in porfusion fluid caussd in thedominant pacemaker cells: decreases ofamplitude of action potential (APA),maximum diastolic potential (MDP) andmaximum rate of depolarization (MRD);increase of the rate of diastolic depola-rization (RDD); upward shift of take-offpotential (TP); and lengthening of actionpotential duration (APD). However, theaction potential of the latent pacemakercells showed: increases of APA, MDPand MRD; decrease of RDD, downward-shift of TP; and shortening of APD.These results suggest that there was adifferent response to calcium in bothtypes of the pacemaker cells. |
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| Keywords: | Sinoatrial node/physiol Calcium/Physiol ion channels/paysiol Pacemaker cell/physiol Action potentials Animals Rabbits in vitro |
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