Correlation of Resistance to Proflavine and Penicillin in Escherichia coli |
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| Authors: | Robin C. McKellar Colin N. McKenzie Donn J. Kushner |
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| Affiliation: | 1.Department of Biology, University of Ottawa, Ottawa, Ontario, Canada K1N 6N5 |
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| Abstract: | A number of proflavine (PF)-resistant mutants of Escherichia coli B were also resistant to penicillin and cephalothin. Mutants resistant to 1.0 mM PF were 10 times more penicillin resistant than were the PF-susceptible, wild-type cells. Single-step mutants selected for resistance to either PF or penicillin were also resistant to the other drug. None of the resistant mutants tested possessed β-lactamase activity. These results suggest that resistance to PF and penicillin in E. coli B may be due to permeability changes in the cell envelope. |
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