Changes of lipolytic enzymes cluster with insulin resistance syndrome |
| |
Authors: | P Knudsen J Eriksson S LahdenperÄ J Kahri L Groop Professor M -R Taskinen |
| |
Institution: | (1) Third Department of Medicine, University of Helsinki, Haartmaninkatu 4, FIN-00290 Helsinki, Finland;(2) Fourth Department of Medicine, University of Helsinki, Helsinki, Finland;(3) Department of Endocrinology, University of Lund, Malmö General Hospital, Malmö, Sweden |
| |
Abstract: | Summary The activities of hepatic and lipoprotein lipase and the levels of lipo- and apoproteins were compared in two groups of normoglycaemic men representing the highest (n=18) and lowest (n=15) fasting insulin quintiles of first degree male relatives of non-insulin-dependent diabetic patients. The high insulin group representing insulin-resistant individuals had significantly lower post-heparin plasma lipoprotein lipase activity than the low insulin group (14.2±4.0 vs 20±5.8 mol NEFA·ml–1·h–1, p<0.001); hepatic lipase activity did not differ between the two groups (24.2±11 vs 18.0±5.3 mol NEFA·ml–1·h–1, NS). The lipoprotein lipase/hepatic lipase ratio in the high insulin group was decreased by 66% as compared to the low insulin group (0.75±0.57 vs 1.25±0.65, p<0.01). In the high insulin group both total and VLDL triglycerides were higher than in the low insulin group (1.61±0.57 vs 0.86±0.26 mmol/l, p< 0.001 and 1.00±0.47 vs 0.36±0.16 mmol/l, p<0.001, respectively) whereas HDL cholesterol and HDL2 cholesterol were lower (1.20±0.30 vs 1.43±0.22 mmol/l, p<0.05 and 0.49±0.21 vs 0.71±0.17 mmol/l, p<0.05, respectively). Total cholesterol, LDL cholesterol or HDL3 cholesterol did not differ between the two groups. The mean particle size of LDL was smaller in the high insulin group than in the low insulin group (258±7 vs 265±6 å, p<0.05). We propose that the changes of lipoprotein lipase and lipoprotein lipase/hepatic lipase ratio cluster with insulin resistance and provide a possible mechanism to explain the lowering of HDL cholesterol and elevation of triglyceride concentrations observed in insulin-resistant subjects.Abbreviations LPL
Lipoprotein lipase
- HL
hepatic lipase
- VLDL
very low density lipoprotein
- IDL
intermediate density lipoprotein
- LDL
low density lipoprotein
- HDL
high density lipoprotein
- chol
cholesterol
- TG
triglycerides
- NEFA
non-esterified fatty acids |
| |
Keywords: | Insulin resistance lipase activities lipoproteins |
本文献已被 SpringerLink 等数据库收录! |
|