杠板归抗炎止咳作用的实验研究

目的观察杠板归的抗炎止咳作用。方法采用二甲苯致小鼠耳廓肿胀实验、醋酸致小鼠腹腔毛细血管通透性亢进实验和角叉菜胶致大鼠足趾肿胀实验观察杠板归消炎作用;采用SO2引咳法观察其止咳作用及大鼠毛玻璃管排痰法观察其化痰作用。结果杠板归提取物能明显抑制二甲苯致小鼠耳廓的肿胀度,抑制醋酸所致小鼠腹腔毛细血管通透性的增高,降低角叉菜胶致足趾肿胀大鼠血清和足爪局部炎症组织中前列腺素（PGE2）、丙二醛（MDA）的含量;杠板归能延长SO2引咳的咳嗽潜伏期、减少咳嗽次数、促进大鼠排痰量。结论杠板归有抗炎、止咳化痰作用。

Experimental study on the effect of relieving cough and reducing sputum of polygonum perfoliatum L

Objective To observe the effect of relieving cough and reducing sputum of polygonum perfoliatum L.Methods The methods of making ear swelling by xylene,making abdominal capillary permeability hyp-erthyroidism in mice by acetic acid and toes＇swelling medle caused by carrageenin in rats to observe the effect of polygonum perfoliatum L;Tussive models induced by SO2 in mice were used to observe the effects of relieving cough and reducing sputum of polygonum perfoliatum L;Glass expectoration method in rats were used to observe reducing sputum effects of polygonum perfoliatum L.Results Polygonum perfoliatum L owned extract significantly inhibited xylene-induced ear swelling,inhibition of capillary permeability in mice induced by acetic acid in the higher and lower carrageenan induced paw edema and paw partial serum inflammatory tissue prostaglandin（PGE2）,malondialdehyde（MDA）content;Polygonum perfoliatum L went to extend the SO2 cough cough latency,reduced cough frequency,the amount of rat expectoration.Conclusion Polygonum perfoliatum L has the effects of antiinflammatory,reducing sputum and relieving cough.