舒芬太尼复合丙泊酚预防全麻拔管期心血管反应的临床观察

目的观察舒芬太尼复合丙泊酚预防全麻拔管期心血管反应的效果及安全性。方法将择期行腹腔镜下阑尾切除术患者60例,随机分为观察组和对照组,各30例。观察组气管拔管前静脉滴注舒芬太尼0.5μg/kg和丙泊酚0.5～1.0mg/kg,2～3min后予吸痰拔管;对照组直接吸痰拔管。结果观察组在拔管时和拔管后5、10minHR、SBP、DBP、RPP与用药前比较,差异无统计学意义（P〉0.05）。对照组拔管时各项指标与用药前比较,明显升高（P〈0.01）,拔管后5、10min各项指标均未恢复到用药前水平（P〈0.05）;观察组拔管时和拔管后5min、10minHR、SBP、DBP、RPP均低于对照组,差异均有统计学意义（P〈0.01）。2组呼吸恢复时间、苏醒时间及拔管时间比较差异无统计学意义（P〉0.05）。结论全麻患者在气管拔管前应用丙泊酚和舒芬太尼能有效预防心血管的不良反应。

Clinical observation of sulfentanyl combined propofol to prevent cardiovascular reactivity in all linen endotracheal extubation period

Objective To observe the effectiveness and security of sulfentanyl combined propofol to prevent cardiovascular reactivity in all linen endotracheal extubation period.Methods 60 cases patients were randomly divided into observation group and control group,each of 30 cases. Before endotracheal extubation,patients of observation group were gave sulfentanyl 0.5μg/kg and propofol 0.5~1.0mg/kg,after 2~3min gave endotracheal extubation;Patients of control group direct were gave endotracheal extubation.Results The level of HR,SBP,DBP and RPP at pull on the tube and draw after 5,10min in observation group compared with before used medicine,the defference had no statistical significance（P0.05）.All with the former at period of endotracheal extubation in control group were riser than that before used medicine（P0.01） and after 5,10min all not yet returned to the first level（P0.01）;The level of HR,SBP,DBP and RPP at pull on the tube and draw after 5,10min in observation group were lower than that in control,the defference had statistical significance（P0.01）.The lungs time,wake-up time and time of endotracheal extubation of two groups had no statistical significance（P0.05）.Conclusion Sulfentanyl combined propofol used before endotracheal extubation can prevent cardiovascular reactivity.