| 苦参碱及其衍生物合成及生物活性研究进展 |
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| 引用本文： | 何雄,韦星船,田裕昌,赖家雄. 苦参碱及其衍生物合成及生物活性研究进展[J]. 中国现代应用药学, 2011, 28(9): 816-823 |
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| 作者姓名： | 何雄 韦星船 田裕昌 赖家雄 |
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| 作者单位： | 广州大学化学化工学院，广州 510006;广州大学化学化工学院，广州 510006;广州大学化学化工学院，广州 510006;广州大学化学化工学院，广州 510006 |
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| 摘 要： | 目的综述苦参碱及其衍生物的最新研究进展。方法通过查阅大量相关文献,对苦参碱及其衍生物的合成和药理活性资料进行整理、分析,并总结了一部分化合物的构效关系。结果与结论大多数苦参碱衍生物在抗肿瘤、抑菌、抗炎镇痛等方面的生物活性都有较大的提高。
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| 关 键 词： | 苦参碱 苦参碱衍生物 合成 生物活性 药理活性 |
| 收稿时间： | 2010-11-10 |
Advances in Synthesis and Biological Activity of Matrine and Its Derivatives |
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| HE Xiong,WEI Xingchuan,TIAN Yuchang and LAI Jiaxiong. Advances in Synthesis and Biological Activity of Matrine and Its Derivatives[J]. The Chinese Journal of Modern Applied Pharmacy, 2011, 28(9): 816-823 |
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| Authors: | HE Xiong WEI Xingchuan TIAN Yuchang LAI Jiaxiong |
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| Affiliation: | School of Chemistry and Chemical Engineering, Guangzhou University, Guangzhou 510006, China;School of Chemistry and Chemical Engineering, Guangzhou University, Guangzhou 510006, China;School of Chemistry and Chemical Engineering, Guangzhou University, Guangzhou 510006, China;School of Chemistry and Chemical Engineering, Guangzhou University, Guangzhou 510006, China |
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| Abstract: | OBJECTIVE To introduce advances in research of matrine and its derivates. METHODS Based on the correlative materials from documents, the synthesis and pharmacology of matrine and its derivates had been briefly summarized. The structure-activity relationship of some matrine derivates was included. RESULTS & CONCLUSION Many bioactivities of matrine derivates have been improved greatly, such as antitumor, antisepsis, anti-inflammation and analgesicis. |
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| Keywords: | matrine derivatives synthesis biological activity pharmacology |
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