| 甲状腺乳头状癌患者外周血CD4+CD25+CD127low/-Treg的检测及其临床意义 |
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| 引用本文： | 石嘉俪,周佳青. 甲状腺乳头状癌患者外周血CD4+CD25+CD127low/-Treg的检测及其临床意义[J]. 中国肿瘤生物治疗杂志, 2011, 18(5): 544-547. DOI: 10.3872/j.issn.1007-385X.2011.05.015 |
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| 作者姓名： | 石嘉俪 周佳青 |
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| 作者单位： | 上海交通大学医学院附属仁济医院耳鼻咽喉头颈外科,上海,200127 |
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| 摘 要： | 目的:检测CD4+ CD25+ CD127low/-调节性T细胞(regulatory T cell,Treg)在甲状腺乳头状癌(papillary thyroid carcinoma,PTC)患者外周血的比例,探讨其临床意义。方法:选择2010年8月至2011年2月在上海交通大学医学院附属仁济医院进行手术治疗的PTC患者40例及甲状腺腺瘤患者30例,以CD4+ CD25+ CD127low/-为标志,采用流式细胞术检测PTC患者及甲状腺腺瘤患者外周血中CD4+ CD25+ CD127low/-Treg的比例,分析其与PTC临床病理特征的关系。结果:与甲状腺腺瘤患者比较,PTC患者外周血中CD4+ CD25+ CD127low/- Treg比例明显升高[(7.836±1.668)% vs(5.365±1.156)%,P<0.05];外周血CD4+ CD25+ CD127low/-Treg比例与PTC临床分期、颈部淋巴结转移相关(均P<0.05),与年龄、性别及肿瘤大小无关(P>0.05)。结论:PTC患者外周血CD4+ CD25+ CD127low/-Treg比例显著增加,且与PTC临床分期、颈部淋巴结转移相关。
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| 关 键 词： | 甲状腺乳头状癌 CD4+ CD25+调节性T细胞 颈部淋巴结转移 TNM分期 |
| 收稿时间： | 2011-06-15 |
| 修稿时间： | 2011-09-20 |
Detection and clinical significance of CD4+CD25+CD127low/- regulatory T cell in peripheral blood of papillary thyroid carcinoma patients |
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| SHI Jia li and ZHOU Jia qin. Detection and clinical significance of CD4+CD25+CD127low/- regulatory T cell in peripheral blood of papillary thyroid carcinoma patients[J]. Chinses Journal of Cancer Biotherapy, 2011, 18(5): 544-547. DOI: 10.3872/j.issn.1007-385X.2011.05.015 |
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| Authors: | SHI Jia li and ZHOU Jia qin |
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| Affiliation: | Department of Otorhinolaryngology Head and Neck Surgery, Renji Hospital, Medical School of Shanghai Jiaotong University, Shanghai 200127, China;Department of Otorhinolaryngology Head and Neck Surgery, Renji Hospital, Medical School of Shanghai Jiaotong University, Shanghai 200127, China |
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| Abstract: | Objective:To evaluate the propotion of CD4+ CD25+ CD127low/- regulatory T cells in peripheral blood of papillary thyroid carcinoma(PTC) patients and its clinical significance.Methods: Forty patients with PTC and 30 patients with thyroid adenoma were included in this study.They were all treated in Renji Hospital,Medical School of Shanghai Jiaotong University between August 2010 to February 2011.The proportion of CD4+ CD25+ CD127low/- Treg in peripheral blood of PTC and thyroid adenoma patients was evaluated ... |
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| Keywords: | papillary thyroid carcinoma CD4+CD25+ regulatory T cell cervical lymph node metastasis TNM stage |
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