糖耐量减低肥胖儿童胰岛素原和真胰岛素水平测定意义

目的　探讨血清胰岛素原 (PI)及真胰岛素 (TI)测定对肥胖并糖耐量异常患儿的临床意义。方法　选择肥胖并糖耐量减低 (IGT)患儿 2 1例 ,肥胖糖耐量正常 (NGT) 5 2例 ,正常对照组 4 0例。测定各组空腹血清PI、TI、血糖 (G)、胰岛素 (I)和C 肽 (C P) ,并计算PI/I、PI/C P、PI/TI及胰岛素抵抗指数。结果　 1.肥胖并IGT和并NGT两组患儿比较 ,G、PI、C P及胰岛素抵抗指数均明显增加 (P均 <0 .0 1)。 2 .IGT组糖尿病阳性家族史明显高于NGT组 (P =0 .0 2 4 )。结论　高PI、高C P和胰岛素抵抗是肥胖并IGT患儿的突出表现 ,可能是儿童2型糖尿病的预示指标。有糖尿病阳性家族史肥胖儿童更应警惕IGT发生

Significance of measuring serum proinsulin and true insulin in obese children with impaired glucose tolerance

Objective To investigate clinical significance of proinsulin and true insulin in obese children with impaired glucose tolerance (IGT).Methods There were 21 IGT and 52 normal glucose tolerance (NGT) children. Control cases were 40 normal children. The levels of serum fasting proinsulin,true insulin,insulin,c-peptide and glucose were measured in all the subjects.Results 1.Levels of fasting proinsulin,c-peptide, glucose, insulin, true insulin and homeostasis insulin resistance in obese children with IGT showed significant difference compared with NGT (P<0.01). 2.Obese children with IGT had higher frequencies of positive family history than NGT ones.Conclusion The elevated levels of proinsulin,c-peptide and increased insulin resistance are major presentation of IGT obese children, which run higher risk of developing diabetes.