替米沙坦对原发性高血压伴左心室肥厚的疗效观察

目的探讨替米沙坦对原发性高血压伴左室肥厚患者的疗效观察。方法 84例原发性高血压伴左心室肥厚患者停用降压药2周后被随机分为两组,治疗组给予替米沙坦80mg,每天1次,对照组给予卡托普利25mg,每天3次,药物剂量根据患者血压情况调整,观察6个月;比较两组病人治疗前后血压、左心室肥厚超声心动图指标变化。结果治疗组与对照组血压均降低,治疗前后差异显著(P<0.01),两组比较差异无显著意义(P>0.05);两组左心室肥厚均逆转,治疗前后差异显著(P<0.05),两组相比差异无显著意义(P>0.05)。结论替米沙坦与卡托普利均能有效地降低血压,同时逆转左心室肥厚。

Effect of Telmisartan on Essential Hypertension and Left Ventricular Hypertrophy

Objective To discuss the effect of telmisartan on patients with essential hypertension and left ventricular hypertrohpy.Methods 84 patients with essential hypertension and left ventricular hypertrohpy who ceased to take antihypertensive drugs two weeks later,were randomly divided into two groups.The treatment group were taken telmisartan 80 mg,qid,and the control group were taken captopril 25 mg,tid.Medicine doses were adjusted with the changes of blood pressure,for clinical observation of 6 months.The blood pressure and left ventricular hypertrophy before and after treatment were compared between the two groups.Results The blood pressure in both the treatment group and the control group reduced,with significant difference before and after treatment(P <0.01),but without comparatively significant difference between the two groups(P >0.05);left ventricular hypertrophy in the two groups were reversed,with significant difference before and after treatment(P <0.01),but without comparatively significant difference between the two groups(P >0.05).Conclusions Telmisartan and captopril can effectively reduce blood pressure,and reverse left ventricular hypertrophy as well.