| 降血脂药物的研究:新的芳氧异丁酸类化合物的合成 |
| |
| 引用本文： | 张永,王慧才. 降血脂药物的研究:新的芳氧异丁酸类化合物的合成[J]. 药学学报, 1985, 20(11): 827-831 |
| |
| 作者姓名： | 张永 王慧才 |
| |
| 作者单位： | 山东医学院药学系 济南(张永)，山东医学院药学系 济南(王慧才) |
| |
| 摘 要： | 为了寻找高效低毒的降血脂药物,合成了22个芳氧异丁酸类化合物。其中4个化合物(1,12,16,18)的动物筛选实验表明:2,5-二甲苯氧异丁酸乙酯(化合物16)的降血脂效果优于安妥明且毒性小。
|
| 关 键 词： | 降血脂药物 芳氧异丁酸类化合物 安妥明 2,5-二甲苯氧异丁酸乙酯 |
| 收稿时间： | 1984-11-06 |
STUDIES ON DRUGS USED FOR THE TREATMENT OF HYPERLIPOPROTEINEMIA: SYNTHESIS OF NEW ARYLOXYISOBUTYRIC ACID DERIVATIVES |
| |
| ZHANG Yong and WANG Hui-Cai. STUDIES ON DRUGS USED FOR THE TREATMENT OF HYPERLIPOPROTEINEMIA: SYNTHESIS OF NEW ARYLOXYISOBUTYRIC ACID DERIVATIVES[J]. Acta pharmaceutica Sinica, 1985, 20(11): 827-831 |
| |
| Authors: | ZHANG Yong and WANG Hui-Cai |
| |
| Abstract: | In order to search for effective hypolipidemic drugs, twenty-two aryloxyisobutyric acid derivatives were prepared. Results of animal screening tests of four of those compounds (1, 12, 16, 18) showed that ethyl 2,5-dimethylphenoxyisobutyrate (16) is more effective and less toxic than Clofibrate. |
| |
| Keywords: | Hypolipidemic drugs Aryloxyisobutyric acid derivatives Clofibrate Ethyl 2 5-dimethylphenoxyisobutyrate |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《药学学报》浏览原始摘要信息 |
|
点击此处可从《药学学报》下载全文 |
