基于肠道菌群探讨中医药干预多囊卵巢综合征

肠道菌群与多囊卵巢综合征(polycystic ovary syndrome,PCOS)的发病存在相关性。黄连素、葛根素、多糖类等中药单体及参苓白术散、苍附导痰丸等中药复方均可有效调节肠道菌群的生态结构,改善胰岛素抵抗或高雄激素血症,多方面、多机制干预PCOS,疗效独特,临床接受度高。而中医针灸具有扶正祛邪之功,可改变肠道菌群分布,介导Toll样受体4(Toll-like receptor 4,TLR4)下游通路,调节炎性因子表达,改善胰岛素抵抗。目前,对肠道菌群失调致PCOS的发病机制研究尚不够系统,中医药干预PCOS的相关研究还局限于改善胰岛素抵抗及高雄激素血症等临床表现,亟需大量的临床研究及实验研究为其提供证据。

Discussion on the Intervention of Chinese Medicine on Polycystic Ovary Syndrome Based on Intestinal Flora

There is a correlation between the intestinal flora and the onset of polycystic ovary syndrome(PCOS).Berberine,puerarin,polysaccharides and other Chinese medicine monomer and Shenling Baizhu powder,Cangfu Daotan pill and other Chinese medicine compound can effectively regulate the ecological structure of intestinal flora,improve insulin resistance or hyperandrogenemia,and intervene PCOS in many aspects and mechanisms,with unique curative effect and high clinical acceptance.Acupuncture and moxibustion of Chinese medicine has the function of strengthening the body and eliminating pathogenic factors.It can change the distribution of intestinal flora,mediate the downstream pathway of Toll-like receptor 4(TLR4),regulate the expression of inflammatory factors and improve insulin resistance.At present,the research on the pathogenesis of PCOS caused by intestinal flora imbalance is not systematic enough.The related research of Chinese medicine intervention on PCOS is still limited to improving the clinical manifestations of insulin resistance and hyperandrogenemia.A large number of clinical and experimental studies are urgently needed to provide evidence for PCOS.