骨纤维结构不良的流行病学与临床分析

目的 分析单中心30年来收治的骨纤维结构不良患者的流行病学特征和临床特点。方法 我院在1991年到2020年共有744例病理明确诊断为骨纤维结构不良的患者住院接受外科治疗，所有患者的流行病学特征包括年龄、性别、部位，临床特征包括发或多发、是否发生病理骨折及恶变情况进行分析。结果 744例患者共有1 183处病变，患者入院时平均年龄31.1±13.5岁，男女比例接近1:1。最常见的部位是下肢916处（77.4%），其次是上肢106处（9.0%）。下肢最常见的部位是股骨645处（54.5%）和胫骨224处（18.9%）。多发占25.4%，单发占74.6%。就诊时发生病理骨折的患者163例（13.8%）。发生恶变的患者有6例（0.8%），平均年龄40.5岁（32~47）岁，平均恶变时间为7.7年。结论 骨纤维结构不良是一组罕见的良性骨肿瘤，具有典型的流行病学特征和临床特点。

Epidemiological and Clinical Characteristics of Fibrous Dysplasia of Bone

Objective To describe the epidemiological and clinical characteristics of fibrous dysplasia of bone admitted to a single center in the past 30 years. Methods We analyzed the clinical features of 744 patients with bone fibrous dysplasia diagnosed by pathology, including age, gender, disease location, monostotic or polyostotic lesions, pathological fracture and malignant transformation. Results There were 1183 lesions in 744 patients. The mean age at admission was 31.1±13.5 years old. The ratio of male to female was close to 1:1. The most common site was the lower extremities (916(77.4%)), followed by the upper extremities (106(9.0%)). The most common sites of lower extremities were the femur (645(54.5%)) and the tibia (224(18.9%)). Polyostotic cases accounted for 25.4%, and monostotic cases accounted for 74.6%. Pathological fracture occurred in 163 (13.8%) patients. There were 6 (0.8%) patients with malignant transformation. The mean age was 40.5 years old. The mean time of malignant transformation was 7.7 years. Conclusion Fibrous dysplasia of bone is a rare group of benign bone tumors, with typical epidemiological and clinical features.