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Investigating the effects of walnut ointment on non-healing burn wounds |
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| Authors: | Qian Chen Xingwang Deng Lijuan Qiang Ming Yao Lifeng Guan Nan Xie Dan Zhao Jiaxiang Ma Liqiong Ma Yinsheng Wu |
| Institution: | 1. School of Clinical Medicine, Ningxia Medical University, Ningxia, China;2. Department of Burns and Plastic Surgery, Xinyang Central Hospital, Henan, China;3. Department of Burns and Plastic Surgery, The First People’s Hospital of Shizuishan, Ningxia, China;4. Department of Burns and Plastic Surgery, People’s Hospital of Ningxia Hui Autonomous Region, Ningxia, China;5. Department of Burns and Plastic Surgery, General Hospital of Ningxia Medical University, Ningxia, China;6. Clinical Medicine Research Center, National Health Commission, Beijing National Health Hospital, Beijing, China;7. Tissue Organ Bank & Tissue Engineering Centre, General Hospital of Ningxia Medical University, Ningxia, China;8. Department of Pathology, General Hospital of Ningxia Medical University, Ningxia, China;9. School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, Australia |
| Abstract: | Effective treatments for non-healing burn wounds are an unmet need for 95% of burn sufferers. Approaches currently available to treat non-healing burn wounds are not satisfactory due to undesirable side-effects or expense. The anti-oxidation and antibacterial activities of walnuts are recommended for treating chronic diseases. Walnut ointment has been developed and successfully applied to treat non-healing burn wounds in our hospital for decades. We report herein a detailed retrospective case review examining patients’ response to the walnut ointment. The walnut ointment has shortened healing time of non-healing burn wounds and improved clinical outcomes. In order to investigate the mechanism of action, walnut ointment has been applied on wounds of porcine full-thickness burn wound models. Histological and immunohistochemical analysis indicated our walnut ointment supports wound healing through promoting keratinocyte proliferation and differentiation. Taken together, we recommend the walnut ointment offers an effective and economical treatment for patients presenting with non-healing burn wounds. |
| Keywords: | Walnut ointment Non-healing burn wounds Wound healing Porcine Full-thickness burn wound models |
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