| 迷走神经刺激对丘脑网状核神经元自发放电的影响 |
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| 引用本文： | 王鹏,焦金菊,常志杰.迷走神经刺激对丘脑网状核神经元自发放电的影响[J].辽宁医学院学报,2007,28(2):24-26. |
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| 作者姓名： | 王鹏 焦金菊 常志杰 |
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| 作者单位： | 辽宁医学院生理学教研室,辽宁,锦州,121001;辽宁医学院生理学教研室,辽宁,锦州,121001;辽宁医学院生理学教研室,辽宁,锦州,121001 |
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| 摘 要： | 目的观察迷走神经刺激(Vagus Nerve Stimulation,VNS)对大鼠丘脑网状核(thalamic reticular nucleus,TRN)神经元自发放电的影响,探讨迷走神经刺激抗癫痫的机制。方法采用玻璃微电极细胞外记录的方法,观察VNS对大鼠TRN神经元自发放电频率的影响。结果迷走神经刺激后,TRN神经元放电频率与刺激前比较明显降低(P<0.01)。结论本实验结果提示VNS可能通过抑制TRN神经元的放电,降低大脑皮层的兴奋性,从而抑制癫痫的形成及发展。
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| 关 键 词： | 迷走神经 癫痫 丘脑网状核 |
| 文章编号： | 1000-5161（2007）02-0024-03 |
| 收稿时间： | 2006-12-11 |
| 修稿时间： | 2006年12月11 |
Effect of Vagus Nerve Stimulation on Firing Activities of TRN Neurons |
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| WANG Peng,JIAO Jin-ju,CHANG Zhi-jie.Effect of Vagus Nerve Stimulation on Firing Activities of TRN Neurons[J].Journal of Liaoning Medical University (LNMU) Bimonthly,2007,28(2):24-26. |
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| Authors: | WANG Peng JIAO Jin-ju CHANG Zhi-jie |
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| Abstract: | Objective This paper has investigated the effect of vagus nerve stimulation on firing activities of thalamic reticular nucleus(TRN) neurons in rats. Methods Extracelluar recording was used to observe the changes of the firing rates and patterns of TRN to VNS. Results After vagus nerve was stimulated,the firing sates of most TRN neurons reduced obviously(p<0.1). Conclusions VNS may reduce the excitability of cerebral cortices by inhibiting the firing rates of TRN so as to inhibit the formation and development of seizures. |
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| Keywords: | vagus nerve epilepsy thalamic reticular nucleus |
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