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Granular cell tumor (Abrikossoff tumor) of the thyroid gland
Authors:Vladimir A. Espinosa-de-los-Monteros-Franco MD, Fernando Martí  nez-Madrigal MD,Carlos Ortiz-Hidalgo MD,
Affiliation:aDepartment of Pathology, The American British Cowdray Medical Center, Mexico D.F. 01120, Mexico;bDepartment of Pathology, Hospital Regional de Zona #1, IMSS, Morelia, Michoacán 58260, Mexico;cDepartment of Pathology, Universidad Michoacana de San Nicolás de Hidalgo School of Medicine, Morelia, Michoacán, Mexico;dDepartment of Tissue and Cell Biology, Universidad Panamericana School of Medicine, Mexico, D.F. 03810, Mexico
Abstract:Only 4 cases of granular cell tumor of the thyroid have been previously reported in the English literature. We report herein the fifth case of this uncommon neoplasm and the first one affecting a male patient. The tumor was well circumscribed and located to the left thyroid lobe, near the isthmus. Histologically, the tumor was composed of large, rounded, granular eosinophilic cells that were immunohistochemically positive for S-100, calretinin, and PGP9.5 and negative for cytokeratin AE1-3, TTF-1, and thyroglobulin.
Keywords:Granular cell tumor   Thyroid
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