Modification of acquired immunity in BALB/c mice by aztreonam |
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Authors: | Ortega E de Pablo M A Gaforio J J Gallego A M Alvarez C Ruiz-Bravo A de Cienfuegos G A |
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Affiliation: | Department of Health Sciences, Faculty of Experimental Sciences, University of Jaén, Spain. eortega@ujaen.es |
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Abstract: | Recent studies have suggested that antibiotics may act as biological response modifiers. In this study we investigated the effect of aztreonam, a monobactam antibiotic, on different parameters of acquired immunity in BALB/c mice. Different dosages of aztreonam injected into mice induced an increase in the lymphoproliferative response to specific mitogens and in the production of interleukin-2 by splenic cells, as well as a decreased response of this immune population to sheep erythrocytes lower total blood cell counts and a lower percentage of monocytes than in untreated mice. These results show a modulatory action of aztreonam on different immune parameters, which is independent of its antimicrobial activity and that could be of interest in human therapy. |
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