| 1，2，3-O-三乙酰基-5-脱氧核糖的合成工艺研究 |
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| 引用本文： | 朱仁发,何勇,陈仕云,邵国泉.1，2，3-O-三乙酰基-5-脱氧核糖的合成工艺研究[J].安徽医药,2008,12(1):11-12. |
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| 作者姓名： | 朱仁发 何勇 陈仕云 邵国泉 |
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| 作者单位： | 1. 合肥学院化学与材料工程系,安徽,合肥,230022
2. 合肥辉佳化工科技有限公司,安徽,合肥,230051 |
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| 摘 要： | 目的抗肿瘤药物中间体1，2，3-O-三乙酰基-5-脱氧核糖的合成。方法以肌苷为起始原料经碘化得5＇-碘代-6-羟基-9-β-D-嘌呤核苷，产物氢化得产物5＇-脱氧-6-羟基-9-β-D-嘌呤核苷，然后经酰化共3步反应合成1，2，3-O-三乙酰基-5-脱氧核糖。结果以肌苷为起始原料经3步反应合成了1，2，3-O-三乙酰基-5-脱氧核糖。结论本合成方法原料价廉易得，工艺简便，条件温和，总收率为38．0％，适合于工业制备。
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| 关 键 词： | 1 2 3-O-三乙酰基-5-脱氧核糖 卡培他滨 化学合成 抗肿瘤 |
| 收稿时间： | 2007-09-17 |
| 修稿时间： | 2007年9月17日 |
Research of synthesis of 1,2,3-O-triacetyl-5-deoxy-D-riboturanose |
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| ZHU Ren-fa,HE Yong,CHEN Shi-yun,SHAO Guo-quan.Research of synthesis of 1,2,3-O-triacetyl-5-deoxy-D-riboturanose[J].Anhui Medical and Pharmaceutical Journal,2008,12(1):11-12. |
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| Authors: | ZHU Ren-fa HE Yong CHEN Shi-yun SHAO Guo-quan |
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| Institution: | ZHU Ren-fa, HE Yong,CHEN Shi-yun, SHAO Guo-quan ( 1. Department of Chemical and Materials Engineering, Hefei University, Hefei 230022 ; 2. Hefei Huijia Chemical Sci ＆ Tech Co. ,LTD,Hefei 230051 ) |
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| Abstract: | Aim To synthesize the anticaneer intermediate 1,2,3-O-triaeetyl-5-deoxy-D-Riboturanose. Method 5＇-iodo-6-hydroxy-9-β-D-purine nueleoside was obtained by using inosine as the starting material by the reaction of iodation, after hydrogenolysis obtained 5 ＇- deoxy-6-hydroxy-9-β-D-purine nueleoside, 1,2,3-O-triaeetyl-5-deoxy -D-riboturanose was synthesized with acetylation in 3 steps, Result The anticancer intermediate 1,2,3-O-triacetyl-5-deoxy-D-riboturanose was synthesized by using inosine as the starting material in 3 steps. Conclusion The starting material is very cheap and easy to get, the reaction conditions are moderate and the operation is convenient, and the total yield is 38.0%. This method is suitable for industrial production. |
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| Keywords: | 1 2 3-O-triacetyl-5-deoxy-D-riboturanose capecitabine chemical synthesis antitumor |
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