胃及大肠癌术后区域性动脉灌注化疗和腹腔泵温热灌注化疗的临床应用

目的探索胃及大肠癌术后的治疗、预防复发和转移的方法。方法对50例术后1～12个月胃及大肠癌患者依据化疗方法的不同分为两组:治疗组24例采取区域性动脉灌注化疗联合腹腔泵温热灌注化疗;对照组26例采取术后区域性动脉灌注化疗。跟踪随访12～36个月。结果治疗组生存率提高、术后肝转移率及腹腔内种植率均低于对照组,两者差异有显著性,P值<0.05。结论区域性动脉灌注化疗联合腹腔泵温热灌注化疗疗效明确,安全性高,能有效降低胃及大肠癌术后复发及腹腔内转移,并对术前已有腹腔内转移者能抑制肿瘤生长速度,延长患者生存期。

Clinical application of transarterial and intraperitoneal pump hyperthermia perfusion chemotherapy of stomach and colon carcinomas postoperatively

Objective To evaluate methods of the treatment for preventing cancer recurrence and metastasis after resection of stomach and colon carcinomas.Methods Fifty patients with stomach and colon carcinomas 1-12 months post-operatively were divided into two groups according to the defferent chemotherapy methods.Twenty-four patients in group A were treated by regional transarterial and intraperitoneal pump hyperthermia perfusion chemotherapy.Twenty-six patients in group B were treated by transarterial perfusion chemotherapy as the control.They were followed up for 12-36 months.Results Comparing with group B,the survival rate in group A was higher,and the hepatic metastasis and recurrent rates were lower.This was the obvious difference for the two groups(P < 0.05).Conclusions The joint treatment of regional transarterial and abdominal cavity pump hyperthermia perfusion is evidently effective and safe with effective prevention of cancer recurrence or metastasis.Also it may be helpful to restrain the growth of recurrence and metastasis,prolong the survival period and improve the living quality.(J Intervent Radiol,2006,15: 600-602)