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| 心肌肽素对缺血-再灌流损伤大鼠离体心脏的影响 | |
| 引用本文： | 万华印,孔祥平,易学瑞,宋珍,滕健,范礼理.心肌肽素对缺血-再灌流损伤大鼠离体心脏的影响[J].中草药,2000,31(3):191-193. |
| 作者姓名： | 万华印 孔祥平 易学瑞 宋珍 滕健 范礼理 |
| 作者单位： | 1. 中国人民解放军第458医院传染病中心分子生物学科,广州,510602 2. 中国医学科学院阜外医院临床药理基地 3. 中国医学科学院、中国协和医科大学药物研究所 |
| 基金项目： | 九·五”国家重点科技攻关项目!( No.96-90 2 -0 1-0 4) |
| 摘 要： | 为研究小分子多肽类物质心肌肽素抗心肌缺血－再灌流损伤作用，在大鼠离体Ｌａｎｇｅｎｄｏｆｆ’ｓ心脏缺血－再灌注损伤模型上，观察心肌肽素对室颤（ＶＦ）发生率及心肌生化指标的影响。结果发现：心肌肽素能明显降低离体缺血－再灌流损伤心脏ＶＦ的发生率；剂量依赖性地降低心肌乳酸脱氢酶（ＬＤＨ）活性和丙二醛（ＭＤＡ）含量；提高心肌肌酸磷酸激酶（ＣＰＫ）活性。提示心肌肽素对缺血－再灌流损伤心脏有保护作用，这可能与其 |
| 关 键 词： | 心肌肽素 中药 大鼠 心肌缺血 再灌注损伤 |
| 收稿时间： | 1999/5/18 0:00:00 |
| 修稿时间： | 1999-05-18 |
Effect of Cardiomyopeptidin on Isolated Rat Heart Injured by Ischemia-Reperfusion |
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| Wan Huayin,Kong Xiangping,Yi Xuerui,Song Zhen,Teng Jian and Fan Lili.Effect of Cardiomyopeptidin on Isolated Rat Heart Injured by Ischemia-Reperfusion[J].Chinese Traditional and Herbal Drugs,2000,31(3):191-193. | |
| Authors: | Wan Huayin Kong Xiangping Yi Xuerui Song Zhen Teng Jian and Fan Lili |
| Institution: | Department of Molecular Biology, the Infectious Disease Center of No. 458 Hospital of PLA, Guangzhou 510602;Department of Molecular Biology, the Infectious Disease Center of No. 458 Hospital of PLA, Guangzhou 510602;Department of Molecular Biology, the Infectious Disease Center of No. 458 Hospital of PLA, Guangzhou 510602;Institute of Materia Medica, Chinese Academy of Medical Sciences;Institute of Materia Medica, Chinese Academy of Medical Sciences;Institute of Materia Medica, Chinese Academy of Medical Sciences |
| Abstract: | Effects of the low molecular weight polypeptide cardiomyopeptidin (CMP) on ischemia reperfusion injury (IRI) inflicted on myocardium of the Langendorff model of isolated rat heart were studied. The results showed that CMP could obviously decrease the incidence of ventricular fibrillation in heart damaged by IRI; reduce the activity of LDH and MDA content and increase the activity of CPK in anterior wall of ventricular myocardium in a dose dependent manner. The results indicated that CMP had a protective effect on IRI infliction of the myocardium which be related to its inhibitory effect on lipid peroxidation and influencing the activities of myocardial enzymes. |
| Keywords: | cardiomyopeptidin ischemia reperfusion injury myocardial enzyme lipid peroxidation |
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