常规MRI和DWI对肾上腺脑白质营养不良演变过程的探讨

目的:探讨常规MRI和磁共振扩散加权成像(DWI)的信号与肾上腺脑白质营养不良(ALD)病理改变的对应性。方法:回顾性分析14例ALD的常规MRI和DWI不同区域病变的图像表现,比较病变不同位置和不同病程的信号变化。结果:最早发生病变的枕顶叶脑白质区域表现为长T1、长T2信号,FLAIR为低信号,DWI为低信号。向前扩展的病变区边缘表现为稍长T2信号,FLAIR为高信号,DWI为高信号,上述两者交界区域在DWI为稍高信号,常规MRI未能显示信号强度的差别。结论:常规MRI和DWI相结合可为动态观察脑白质营养不良的空间-时间演变过程提供影像学诊断依据。

Assessment of Lesion Progression of Adrenoleukodystrophy by the Conventional MR Imaging and DWI

Objective:To analyze and assess retrospectively the conventional MR imaging and diffusion-weighted imaging (DWI) findings corresponding the pathologic progression in adrenoleukodystrophy (ALD).Methods:The characteristics of conventional MR and DWI imaging were analyzed in 14 children with ALD,and the signal variations in different regions and courses of disease were compared.Results:Initial lesions in occipital-parietal lobes showed high T1/T2 signal,low signal on FLAIR,and low signal on DWI.The margin of lesion progression region of frontal lobe revealed moderate T2 signal and high signal on FLAIR,high signal on DWI.However,in junction of above two regions,only significantly high signal on DWI was found,and no differences in the signal intensity on conventional MRI were observed.Conclusion:The combination of conventional MRI and DWI may offer a useful method for dynamic assessment of spatio-temporal progression in ALD.