我国黄连(味连)质量评价研究

目的:探索黄连(味连)成分动态变化,对各主产地黄连作出质量评价。方法:对我国黄连(味连)药材主产地的重庆石柱县及巫溪县、四川洪雅县及大邑县、陕西镇坪县、湖北利川县的黄连样品(3～5年生)进行成分分析比较,以黄连主要生物活性成分小檗碱、黄连碱、药根碱、巴马汀及总生物碱为指标,分别采用HPLC和UV测定其含量。结果与结论:各地黄连(味连)所测指标性成分及总生物碱含量总体上以5年生为高,结合产量等因素考虑,黄连(味连)药材以5年生采挖为宜;各地黄连(味连)在所测指标成分含量上有一定差异,但均符合现行《中国药典》2000年版规定,总体质量情况良好。

Quality assessment of Coptis chinensis in China

Objective: To study the dynamic change of the ingredients of Coptis chinensis and evaluate the quality of the crude drugs from main producing areas. Method: The ingredients of samples from Shizhu and Wuxi counties in Chongqing, Hongya and Dayi counties in Sichuan, Zhenping county in Shanxi, Lichuan county in Hubei were analyzed for berberine, coptisine, jatrorrhizine, palmatine and the total alkaloids by HPLC and UV methods. Result and Conclusion: The contents of measured indexes were mostly highest in 5-years-old C. chinensis. Considering factors such as the yield, it is reasonable to harvest the 5-years-old C. chinensis. There are minor differences in condents of C. chinensis from different areas, all tested samples met the pharmacopoeial standards. It is concluded that the general quality of C. chinensis was good and acceptable.