The effect of age on methacholine response |
| |
Authors: | R J Hopp A Bewtra N M Nair R G Townley |
| |
Affiliation: | From the Allergic Disease Center, Creighton University, Omaha, Neb., USA |
| |
Abstract: | Bronchial reactivity to inhaled methacholine exists in subjects with asthma but may occur in subjects with allergic rhinitis, chronic lung diseases, and during respiratory infections. In the absence of these factors, we found that age also has a significant effect on the methacholine response. One hundred forty-eight subjects, 5 to 76 years of age, were studied as normal control subjects in a natural history of asthma study. The methacholine response was measured by standard techniques. The analysis demonstrated that age had a significant effect on the methacholine response. In addition to known factors influencing the results of methacholine inhalation, young and older subjects may exhibit bronchial responses that may falsely suggest hyperreactive airway disease. |
| |
Keywords: | Forced expiratory flow rate between 25% und 75% of total volume PEFR Peak expiratory flow rate Reprint requests: R. G. Townley, M.D., Allergic Disease Center, Creighton University, 2500 Calif., Omaha, NE 68178. |
本文献已被 ScienceDirect 等数据库收录! |
|