Regulation of 60-kDa heat shock protein expression by systemic stress and 5-hydroxytryptamine in rat colonic mucosa |
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| Authors: | Toshiyuki Kuwabara Michiro Otaka Hideaki Itoh Akira Zeniya Shusei Fujimori Setsuya Otani Yohtalou Tashima Osamu Masamune |
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| Institution: | 1. First Department of Internal Medicine, Akita University School of Medicine, 1-1-1 Hondo, Akita-city, 010, Akita, Japan
2. Department of Biochemistry, Akita University School of Medicine, 1-1-1 Hondo, Akita-city, 010, Akita, Japan
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| Abstract: | Bowel dysfunction such as irritable bowel syndrome caused by stress is well described. Previous reports suggest that 5-hydroxytryptamine (5-HT) mediates alteration of bowel motility. In this study, the effects of water-immersion stress and the administration of 5-HT on the expression of a 60-kDa heat shock protein (HSP60) in rat colonic mucosa were investigated. The effect of YM-060, a 5-hydroxytryptamine 3 (5-HT3) receptor antagonist, on the expression of this protein was also studied. Water-immersion stress and the administration of 5-HT induced synthesis of HSP60 in rat colonic mucosa. The induction of HSP60 and the number of defecations were clearly inhibited by the oral administration of YM-060. Our results suggest that the induction of HSP60 in rat colonic mucosa by water-immersion stress may be associated with gastrointestinal motility mediated by 5-HT, especially via 5-HT3 receptors. |
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