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Analysis of early phase [11C]BF-227 PET,and its application for anatomical standardization of late-phase images for 3D-SSP analysis
Authors:Tomohiro Kaneta  Nobuyuki Okamura  Akira Arai  Kentaro Takanami  Katsutoshi Furukawa  Manabu Tashiro  Shozo Furumoto  Ren Iwata  Shoki Takahashi  Hiroyuki Arai  Kazuhiko Yanai  Yukitsuka Kudo
Affiliation:1. Department of Diagnostic Radiology, Tohoku University, 1-1 Seiryomachi, Aobaku, Sendai, 980-8574, Japan
2. Department of Pharmacology, Tohoku University Graduate School of Medicine, 4-1 Seiryomachi, Aobaku, Sendai, 980-8575, Japan
3. Division of Brain Sciences, Department of Geriatrics and Gerontology, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryomachi, Aobaku, Sendai, 980-8498, Japan
4. Division of Cyclotron Nuclear Medicine, Cyclotron and Radioisotope Center, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai, Miyagi, 980-8578, Japan
5. Division of Radiopharmaceutical Chemistry, Cyclotron and Radioisotope Center, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai, Miyagi, 980-8578, Japan
6. Department of NeuroImaging Research, Innovation New Biomedical Engineering Center, Tohoku University, 4-1 Seiryomachi, Aobaku, Sendai, 980-8498, Japan
Abstract:

Purpose

To examine the usefulness of the early phase [11C]BF-227 positron emission tomography (PET) for (1) conferring additional diagnostic value by providing perfusion-like information and (2) obtaining the appropriate anatomical standardization (AS) using three-dimensional stereotactic surface projection (3D-SSP) method.

Methods

This study included 20 mild cognitive impairment (MCI), 19 Alzheimer’s disease (AD), and 17 normal cognitive (NC) subjects. Early- and late-phase BF-227 PET images were obtained 0–10 and 40–60 min after the injection, respectively. AS for late-phase BF-227 images were performed by 2 methods: (1) method A, for AS of late-phase BF-227 images using 8F-fluorodeoxyglucose (FDG) images of the same subject and (2) method B, for AS of late-phase BF-227 images using early phase BF-227 images.

Results

Method B was successfully used for AS in all cases. The Z score maps of 3D-SSP analyses of FDG PET and early phase BF-227 PET for AD and MCI groups showed a typical AD-like pattern. Regional analyses revealed that the early phase BF-227 PET showed significant differences between AD and NC, and MCI and NC.

Conclusion

The early phase BF-227 PET images showed significant abnormal findings for the AD and MCI groups. AS of late-phase BF-227 images using early phase BF-227 images were successful, and enabled appropriate 3D-SSP analyses.
Keywords:
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