两种药物组合治疗老年患者骨质疏松症的效果比较

目的探讨不同药物组合对明园地区少数民族骨质疏松患者的治疗效果。方法通过完全随机化对照研究,选择新疆油田公司明园职工医院2011-08/2012-07期间明园地区少数民族骨质疏松患者共200人随机分为两组各100例,A组：钙尔奇D＋骨化三醇,B组：钙尔奇D＋骨化三醇＋阿仑磷酸钠,两组均进行药物治疗观察1年,观察药物治疗期间的骨密度和疼痛变化,从药物疗效、依从性、骨折发生率等多方面进行研究。结果两组治疗后骨密度均明显上升,与治疗前比较有统计学意义。治疗后,B组骨密度明显高于对照组,差异有统计学意义（P〈0.05）。结论钙剂和维生素D基础上联合抗骨吸收药物阿仑磷酸钠,1年后可明显提高骨密度,且降低新发骨折的发生率。

Effect Comparison of Two Kind of Combination Drugs in Treating Elder Patients With Osteoporosis

Objective To study the therapeutic effects in treating elder patients with osteoporosis with two kinds of combination drugs. Methods A total of 200 minority patients with osteoporosis visiting Mingyuan Worker＇s Hospital of Xinjiang Oil Filed Co. during Aug,2011 to Jul.,2012 were recruited and randomly divided into two groups. A group was treated with Caltrate ＋ calcitriol and B group was treated additionally with Alendronate. The two groups were observed for one year with indicators of bone mineral density（ BMD） and pain change. BMD,compliance and occurrence rate of fracture were investigated. Results The BMD in the two groups all increased significantly after treatment than pre-treatment. After treatment,BMD of B group was higher than that in A group（ P〈0. 05）. Conclusion Drug combination of calcium,vitamin D and Alendronate could significantly increase the BMD and lower the occurrence rate of bone fracture.