Kappa-bungarotoxin blockade of nicotine electrophysiological actions in cerebellar Purkinje neurons |
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Authors: | R de la Garza R Freedman B J Hoffer |
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Affiliation: | Veterans Administration Medical Center, Denver, CO. |
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Abstract: | The agonistic actions of nicotine in cerebellum were selectively blocked by kappa-bungarotoxin depending on the cell type studied. Nicotine-induced Purkinje cell inhibitions were antagonized by the simultaneous application of this toxin. In contrast, nicotine-induced cerebellar interneuron excitations were unaltered. These findings suggest that kappa-bungarotoxin may be used as a selective pharmacological tool for the study of nicotine actions which are dependent on ganglionic-like receptors, which have been associated with Purkinje cells in previous studies. |
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