NGAL在83例结、直肠癌中的表达及其临床意义 |
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引用本文: | 张秀峰,张筱骅,周素梅,黄卡特,陈国荣.NGAL在83例结、直肠癌中的表达及其临床意义[J].肿瘤学杂志,2009,15(2):115-119. |
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作者姓名: | 张秀峰 张筱骅 周素梅 黄卡特 陈国荣 |
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作者单位: | 温州医学院附属第一医院,浙江温州,325000 |
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摘 要: | 目的]探讨NGAL在结、直肠癌组织中的表达及其临床意义。方法]应用免疫组化法检测NGAL在83例结、直肠癌及癌旁正常组织中的表达,分析其与结、直肠癌临床病理特征及预后的关系。结果]NGAL在结、直肠癌组织中的阳性表达率为55.4%,明显高于在相应癌旁正常组织中的表达(P〈0.001),NGAL表达与结、直肠癌分化程度、Dukes分期、淋巴结转移、脉管侵犯(P〈0.05)有关,而与患者年龄、性别、部位、肿瘤直径、肿瘤大体形态、病理类型、癌性肠梗阻无关(P〉0.05)。单因素生存分析显示NGAL阳性表达组5年无复发生存率低于阴性组,差异有统计学意义(P=0.022)。结论]NGAL阳性表达与结、直肠癌浸润、转移、预后不良有关,NGAL可能是结、直肠癌早期诊断、监测复发的潜在生物学参考指标。
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关 键 词: | 结直肠肿瘤 中性粒细胞明胶酶相关载脂蛋白 免疫组织化学 |
NGAL Expression in 83 Cases with Colorectal Cancer and Its Clinical Significance |
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Institution: | ZHANG Xiu-feng, ZHANG Xiao-hua, ZHOU Su-mei, et al. (The First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, China) |
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Abstract: | Purpose] To explore the NGAL expression in colorectal cancer and its clinical significance. Methods] The NGAL expression of cancer tissues and their adjacent was detected of immunohistochemically in 83 cases with colorectal cancer tissues. Its relationship with clinicopathological features and prognosis was analyzed. Results] The positive rate of NGAL expression in colorectal cancer tissues was 55.4%, which was significantly higher than that in the adjacent tissues (P〈0.001). NGAL expression significantly correlated with cell differentiation, Dukes' stage, lymph node metastases and vascular involvement (P〈0.05); however, no significance with age, sex, location and size of tumor, gross morphous, pathological type and the presence of cancerous ileus (P〉0.05). Five years disease-free survival in patients with positive expression of NGAL was lower than that in patients with negative expression (P=0.022) by univariate survival analysis. Conclusion] The positive expression of NGAL closely correlated with invasion, metastasis and poor prognosis of colorectal cancer. NGAL might be a potential biomarker for the early diagnosis and monitoring recurrence for colorectal cancer. |
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Keywords: | eolorectal neoplasms neutrophil gelatinase-associated lipocalin immunohistoehemistry |
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