| 106例广东汉族群体HLA基因频率的分析及其意义 |
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| 引用本文： | 包蓉,方建培,黄绍良,吴燕峰.106例广东汉族群体HLA基因频率的分析及其意义[J].广东医学,2001,22(8):662-664. |
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| 作者姓名： | 包蓉 方建培 黄绍良 吴燕峰 |
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| 作者单位： | 中山医科大学孙逸仙纪念医院岭南脐血库 |
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| 基金项目： | 美国中华医学基金资助项目 (编号 :96630 ) |
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| 摘 要： | 目的 探讨广东汉族群体HLA抗原多态性分布的情况。方法 随机选择了106例广东籍汉族人进行HLA分型。分别采用微量淋巴细胞毒试验及PCR－SSP方法检测了HLAⅠ类，A，B位点及HLAⅡ类DR位点。结果 共检出了HLA－A位点抗原10种，HLA－B位点抗原21种，HLA－DR位点抗原13种，并与北方人群抗原分布进行对比。结论 A11，B46和B60抗原频率比北方人群有显著增高，而A1，A3、B7等抗原则相对减少，显示广东地区汉族人群与北方人群间在HLA多态性分布上有较显著的差异。
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| 关 键 词： | HLA 基因多态性 广东 汉族 基因频率 人白细胞抗原 |
| 修稿时间： | 2001年6月28日 |
Analysis and significance of HLA polymorphism in 106 Guangdong individuals of Han nationality |
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| Bao Rong,Fang Jianpei,Huang Shaoliang,et al..Analysis and significance of HLA polymorphism in 106 Guangdong individuals of Han nationality[J].Guangdong Medical Journal,2001,22(8):662-664. |
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| Authors: | Bao Rong Fang Jianpei Huang Shaoliang |
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| Institution: | Bao Rong,Fang Jianpei,Huang Shaoliang,et al. Lingnan Cord Blood Bank,Sun Yat sen Memorial Hospital,Sun Yat sen University of Medical Sciences,Guangzhou 510120 |
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| Abstract: | Objective To study the polymorphism of HLA antigen in Guangdong Han nationality. Methods 106 persons living in Guangdong province were randomly selected and HLA-A, B and DR typing were measured by microdroplet lymphcytotoxicity test and PCR-SSP. Results 10 HLA-A, 21 HLA-B and 13 HLA-DR antigens were detected. Compared with Han nationality in northern China, the frequency of antigen A11, B46 and B60 in Guangdong Han was higher than that of North Han nationality, but HLA-A1, A3 and B7 antigens were less common. Conclusion There is obvious difference in polymorphism of HLA antigen between Guangdong Han and North Han nationality. |
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| Keywords: | HLA Polymorphism Guangdong |
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