| 血清高迁移率族蛋白B1检测在重症急性胰腺炎鉴别诊断中的应用研究 |
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| 引用本文： | 俞蕾,胡志刚,陈国千,郭继中. 血清高迁移率族蛋白B1检测在重症急性胰腺炎鉴别诊断中的应用研究[J]. 中华医院感染学杂志, 2011, 0(18): 3966-3968 |
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| 作者姓名： | 俞蕾 胡志刚 陈国千 郭继中 |
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| 作者单位： | 1. 南京医科大学附属无锡市人民医院医学检验科,江苏无锡,214023
2. 南京医科大学附属无锡市人民医院消化科,江苏无锡,214023 |
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| 摘 要： | 目的调查急性胰腺炎患者高迁移率族蛋白B1(HMGB1)、C反应蛋白(CRP)、钙(Ca)、白细胞(WBC)、血清淀粉酶(AMY)水平的变化及其临床意义。方法检测30例健康对照者、45例轻症急性胰腺炎(MAP)患者和32例重症急性胰腺炎(SAP)患者的血清HMGB1水平及血清CRP、WBC;分析血清HMGB1水平与血清CRP、WBC等与胰腺炎的关系。结果 SAP、MAP患者血清HMGB1、CRP、WBC水平显著性高于健康对照组,差异有统计学意义(P<0.01);SAP患者血清HMGB1水平(16.2±11.28)ng/ml,显著性高于MAP患者(5.96±3.83)ng/ml;SAP、MAP患者血清CRP、WBC水平比较,差异有统计学意义(P<0.05);以SAP与MAP组作ROC曲线,AMY、HMGB1、CRP、WBC、Ca曲线下面积分别为0.536、0.857、0.727、0.488、0.275;检测灵敏度达到50.0%时AMY、HMGB1、CRP、WBC、Ca对应的特异性分别为44.8%、93.1%、75.9%、37.9%、14.8%,HMGB1的诊断效率最高,其次为CRP。结论胰腺炎患者血清HMGB1水平明显升高,血清HMGB1水平测定可作为评价胰腺炎病变和炎症反应程度的有效指标。
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| 关 键 词： | 胰腺炎 高迁移率族蛋白B1 炎症介质 血清 |
Application of serum HMGB1 level detection in identification and diagnosis of severe acute pancreatitis |
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| YU Lei,HU Zhi-gang,CHEN Guo-qian,GUO Ji-zhong. Application of serum HMGB1 level detection in identification and diagnosis of severe acute pancreatitis[J]. Chinese Journal of Nosocomiology, 2011, 0(18): 3966-3968 |
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| Authors: | YU Lei HU Zhi-gang CHEN Guo-qian GUO Ji-zhong |
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| Affiliation: | (Wuxi People′s Hospital Affiliated to Nanjing Medical University,Wuxi,Jiangsu 214023,China) |
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| Abstract: | OBJECTIVE To investigate the change of serum HMGB1 level of severe acute pancreatitis and its clinical significance.METHODS Serum HMGB1and CRP and WBC levels were determined in 30 healthy individuals and 45 patients of mild acute pancreatitis and 32 patients of severe acute pancreatitis.The correlation between serum HMGB1 level and serum C-reactive protein level or white blood cell count in acute pancreatitis were analyzed.RESULTS The level of serum HMGB1 and CRP and WBC were significantly higher in patient... |
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| Keywords: | Pancreatitis HMGB1 Proinflammatory medium Serum |
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