| 神经系统受累的手足口病患儿脑脊液胱抑素C水平及与病原学关系探讨 |
| |
| 引用本文： | 钱瑛,季亚勇,李琴,陈国千. 神经系统受累的手足口病患儿脑脊液胱抑素C水平及与病原学关系探讨[J]. 中华医院感染学杂志, 2011, 0(19): 4059-4061 |
| |
| 作者姓名： | 钱瑛 季亚勇 李琴 陈国千 |
| |
| 作者单位： | 1. 南京医科大学附属无锡市人民医院检验科,江苏无锡,214023
2. 无锡市疾病预防控制中心微生物科,江苏无锡,214023 |
| |
| 摘 要： | 目的探讨神经系统受累的手足口病患儿脑脊液胱抑素C的检测价值及与病原学的关系。方法对具有神经系统症状的42例手足口病患儿采集咽拭子做柯萨奇病毒A组16型(CA16)和肠道病毒71型(EV71)检测,并采集脑脊液进行常规细胞学、生化和胱抑素C含量的测定,与非病毒性脑膜炎组和对照组进行比较,寻找其中差异。结果手足口病组的脑脊液胱抑素C含量低于非病毒性脑膜炎组和对照组(P<0.01);手足口病组脑脊液白细胞数、多核细胞比例与非病毒性脑膜炎组比较,差异有统计学意义(P<0.05),与对照组比较差异也有统计学意义(P<0.01);手足口病组脑脊液蛋白含量低于非病毒性脑膜炎组(P<0.01),与对照组比较则差异无统计学意义;EV71阳性组与阴性组在脑脊液胱抑素C含量、白细胞、多核细胞比例上差异均有统计学意义(均P<0.01);EV71阳性组脑脊液蛋白结果虽高于阴性组,但差异无统计学意义。结论脑脊液胱抑素C可能是监测手足口病患儿神经系统受累的有用指标,联合脑脊液细胞学和生化检查有鉴别诊断价值。
|
| 关 键 词： | 脑脊液 胱抑素C 手足口病 肠道病毒 |
Relationship between level of cerebrospinal fluid cystatin C in neurological damage children with hand, foot and mouth disease and pathology |
| |
| QIAN Ying,JI Ya-yong,LI Qin,CHEN Guo-qian. Relationship between level of cerebrospinal fluid cystatin C in neurological damage children with hand, foot and mouth disease and pathology[J]. Chinese Journal of Nosocomiology, 2011, 0(19): 4059-4061 |
| |
| Authors: | QIAN Ying JI Ya-yong LI Qin CHEN Guo-qian |
| |
| Affiliation: | (Wuxi People′s Hospital Affiliated of Nanjing Medical University,Wuxi,Jiangsu 214023,China) |
| |
| Abstract: | OBJECTIVE To investigate the value of cerebrospinal fluid(CSF) cystatin C in children with hand,foot and mouth disease(HFMD) with neurological damage and its relationship with pathogens.METHODS Throat swabs from 42 cases with HFMD with neurological damage were collected to detect the enterovirus type 71(EV71) and coxsackie virus group A type 16(CA16).CSF was collected as well to examine cytology and biochemical markers,and Cystatin C,then compared with that of non-virus meningitis group and control group,to... |
| |
| Keywords: | Cerebrospinal fluid Cystatin C Hand foot and mouth disease Enterovirus |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
