新生儿重症监护病房定植菌筛查临床应用研究

目的掌握新生儿重症监护病房(NICU)患儿细菌定植状况及与医院感染关系,为NICU医院感染预防控制提供证据。方法对照组患儿698例,观察组患儿966例;观察组所有患儿在入院时常规进行痰或咽拭子培养,查定植菌和药物敏感试验;比较两组患儿感染率、感染暴发次数、呼吸机相关性肺炎(VAP)发生率。结果对照组698例患儿中,73例发生医院感染,感染率为10.46%,观察组966例患儿中,58例发生医院感染,感染率为6.00%(P<0.05);对照组、观察组VAP发生率分别为2.29%、0.62%(P<0.01),感染暴发分别为2、0次;观察组送检痰和咽拭子标本966份,703份有细菌定植,定植率为72.77%,检出致病定植菌432份,检出率为61.45%;432例致病菌定植患儿发生医院感染51例,感染率11.81%,占总感染例数的87.93%;无致病菌定植患儿发生医院感染7例,感染率1.31%,占总感染例数的12.07%,差异有统计学意义(χ2=37.76,P<0.01);432株致病定植菌中,革兰阴性杆菌282株,占65.28%,革兰阳性球菌占34.72%。结论定植菌筛查可早期评估新生儿感染风险,实现医院感染防控早发现、早诊断、早治疗、早防护原则。

Research on clinical application of colonization bacteria screening in neonatal intensive care unit

OBJECTIVE To master bacteria colonization condition of neonatal intensive care unit(NICU)and provide evidence for hospital infection prevention and control of NICU.METHODS A total of 698 cases in the control group,966 cases in the observation group.sputum culture and throat swab culture had been done when all the neonatal entered the hospital to check colonization bacteria and the drug sensitivity test was made.The hospital infection rate,the infection outbreak times,the VAP originating rate between these t...