Distribution of serotonin-immunoreactivity in the brain of the pigeon (Columba livia) |
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Authors: | E Challet D Miceli J Pierre J Repérant G Masicotte M Herbin and N P Vesselkin |
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Institution: | (1) Laboratoire de Neuromorphologie, INSERM U 106, Hôpital de la Salpêtrière, Bâtiment de Pédiatrie, 47 Boulevard de l'Hôpital, F-75651, 13 Paris Cedex, France;(2) Départment de Psychologie, Université du Québec, Trois-Rivières, Canada;(3) Department de Chimie-Biologie, Université du Québec, Trois-Rivières, Canada;(4) Institute Sechenov, Academy of Science of Russia, St. Petersburg, Russia |
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Abstract: | The distribution of serotonin (5-HT)-containing perikarya, fibers and terminals in the brain of the pigeon (Columba livia) was investigated, using immunohistochemical and immunofluorescence methods combined with retrograde axonal transport. Twenty-one different groups of 5-HT immunoreactive (IR) cells were identified, 2 of which were localized at the hypothalamic level (periventricular organ, infundibular recess) and 19 at the tegmental-mesencephalic and rhombencephalic levels. Ten of the cell groups were situated within the region of the midline from the isthmic to the posterior rhombencephalic level and constituted the raphe system (nucleus annularis, decussatio brachium conjunctivum, area ventralis, external border of the nucleus interpeduncularis, zona peri-nervus oculomotorius, zona perifasciculus longitudinalis medialis, zona inter-flm, nucleus linearis caudalis, nucleus raphe superior pars ventralis, nucleus raphe inferior). The 9 other cell populations belonged to the lateral group and extended from the posterior mesencephalic tegmentum to the caudal rhombencephalon formatio reticularis mesencephali, nucleus ventrolateralis tegmenti, ectopic area (Ec) of the nucleus isthmo-opticus (NIO), nucleus subceruleus, nucleus ceruleus, nucleus reticularis pontis caudalis, nucleus vestibularis medialis, nucleus reticularis parvocellularis and nucleus reticularis magnocellularis]. Combining the retrograde axonal transport of rhodamine -isothiocyanate (RITC) after intraocular injection and immunohistofluorescence (fluoresceine isothiocyanate: FITC/5-HT) showed the centrifugal neurons (NIO, ec) to be immunonegative. Serotonin-IR fibers and terminals were found to be very broadly distributed within the brain and were particularly prominent in several structures of the telencephalon (archistriatum pars dorsalis, nucleus taeniae, area parahippocampalis, septum), diencephalon (nuclei preopticus medianus, magnocellularis, nucleus geniculatus lateralis pars ventralis, nucleus triangularis, nucleus pretectalis), mesencephalon-rhombencephalon (superficial layers of the optic tectum, nucleus ectomamillaris, nucleus isthmo-opticus and in most of the cranial nerve nuclei). Comparing the present results with those of previous studies in birds suggests some major serotonin containing pathways in the avian brain and clarifies the possible origin of the serotonin innervation of some parts of the brain. Moreover, comparing our results in birds with those obtained in other vertebrate species shows that the organization of the serotoninergic system in many regions of the avian brain is much like that found in reptiles and mammals.Abbreviations
Ad
Archistriatum pars dorsalis
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alp
area interpeduncularis
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al
ansa lenticularis
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Ann
nucleus annularis
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APH
area parahippocampalis
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Av
archistriatum pars ventralis
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AVT
area ventralis (Tsai)
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bcd
brachium conjunctivum descendens
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BO
bulbus olfactorius
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ca
commisssura anterior
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CDL
area corticoidea dorsolateralis
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Cer
cerebellum
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cf
fiber layer of the olfactory bulb
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cg
granular cell layer of the olfactory bulb
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co
chiasma opticum
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ct
commissura tectalis
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dbc
decussatio brachiorum conjunctivorum
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DL
nucleus dorsolateralis anterior thalami
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DLP
nucleus dorsolateralis posterior thalami
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DM
nucleus dorsomedialis thalami
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dnt
decussatio nervi trochlearis
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E
ectostriatum
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Ec
ectopic area of the nucleus isthmo-opticus
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EM
nucleus ectomamillaris
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flm
fasciculus longitudinalis medialis
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fpl
fasciculus prosencephali lateralis
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FRL
formatio reticularis lateralis mesencephali
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FRM
formatio reticularis medialis mesencephali
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fu
fasciculus uncinatus
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GCt
substantia grisea centralis
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GLv
nucleus geniculatus lateralis pars ventralis
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gr
granular cell layer of the cerebellum
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HA
hyperstriatum accessorium
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HD
hyperstriatum dorsale
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HIS
hyperstriatum intercalatus superior
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HL
nucleus habenularis lateralis
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HM
nucleus habenularis medialis
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Hp
hippocampus
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HV
hyperstriatum ventrale
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ICo
nucleus intercollicularis
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i-flm
inter fasciculus longitudinalis medialis
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Imc
nucleus ishmi pars magnocellularis
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Ip
nucleus interpeduncularis
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Ipc
nucleus isthmi pars parvocellularis
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LA
nucleus lateralis anterior thalami
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La
nucleus laminaris
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LC
nucleus linearis caudalis
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LHy
nucleus lateralis hypothalami
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lm
lemniscus medialis
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LoC
locus coeruleus
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LPO
lobus paraolfactorius
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ls
lemniscus spinalis
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MLd
nucleus mesencephalicus lateralis pars dorsalis
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mo
molecular layer of the cerebellum
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MoV
nucleus motorius nervi trigemini
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Mp
magnocellularis preopticus
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N
neostriatum
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NIII
nucleus nervi oculomotorii
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nIII
nervus oculomotorius
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NIV
nucleus nervi trochlearis
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NV nucleus nervi trigemini
nV nervus trigeminus
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NVII
nucleus nervifacialis
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nVIII
nervus octavus
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NIO
nucleus isthmo-opticus
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om
tractus occipitomesencephalicus
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OPH
hypothalamic periventricular organ
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Os
nucleus olivaris superior
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Ov
nucleus ovoidalis
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PA
paleostriatum augmentatum
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Po
nucleus pontis
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POM
nucleus preoticus medialis
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PP
paleostriatum primitivum
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PrV
nucleus sensorius principalis nervi trigemini
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PT
nucleus pretectalis
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pu
Purkinje cell layer
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qf
tractus quintofrontalis
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Rai
nucleus raphe inferior
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RasV
nucleus raphe superior pars ventralis
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ReI
recessus infundibularis
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Rm
nucleus reticularis magnocellularis
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Rp
nucleus reticularis parvocellularis
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RPc
nucleus reticularis pontis caudalis
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RPO
nucleus reticularis pontis oralis
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Rt
nucleus rotundus
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Ru
nucleus ruber
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S
septum
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Sac
stratum album centrale
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SCH
stratum cellulare hypothalami
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Sgc
stratum griseum centrale
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Sgf
stratum griseum et fibrosum superficiale
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Sgfp
stratum griseum et fibrosum periventriculare
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Sop
stratum opticum
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SP
nucleus subpretectalis
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SPC
nucleus superficialis parvocellularis
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Spl
nucleus spiriformis lateralis
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Spm
nucleus spiriformis medialis
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SRt
nucleus subrotundus
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SuC
nucleus subcoeruleus
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to
tractus opticus
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Tn
nucleus taeniae
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TPc
nucleus tegmenti pedunculo-pontinus pars compacta
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Tr
nucleus triangularis
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tsm
tractus septomesencephalicus
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ttd
nucleus et tractus descendens nervi trigemini
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Tu
nucleus tuberis
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Vel
nucleus vestibularis lateralis
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Vem
nucleus vestibularis medialis
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Vlt
nucleus ventrolateralis thalami
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VT
nucleus ventrolateralis tegmenti
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Zp-flm
zona perifasciculus longitudinalis medialis
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Zp-NIII
zona perinervus oculomotorius |
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Keywords: | Serotonin Immunohistochemistry Central nervous system Pigeon |
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