参芪扶正注射液对原发性肾病综合征肾小管的保护作用

目的探讨参芪扶正注射液对原发性肾病综合征(PNS)患者肾小管的作用及其机制、方法80例PNS患者随机分成两组。对照组40例，采用常规治疗方法，以糖皮质激素为主，参芪组40例，在常规治疗方法的基础上加用参芪扶正注射液250ml静脉滴注，每日1次，1个月为1个疗程，观察两组治疗前后血浆白蛋白(sALB)、24h尿蛋白定量、尿视黄醇结合蛋白(RBP)、尿β2微球蛋白(β2-MG)、尿乙酰-β-D氨基葡萄糖苷酶(NAG)浓度的变化及血脂水平．结果参芪组治疗后sALB上升，尿RBP、β2-MG、NAG、24h尿蛋白定量下降，与对照组比较差异均有显著性(P＜0．0l，P＜0．05)；两组治疗后血脂水平均比治疗前显著降低(P＜0．01)，两组治疗后比较，参芪组TC及LDL—C显著低于对照组(P＜0．01)．结论参芪扶正注射液对PNS患者的肾小管具有保护作用，并有降脂作用。

Renal Tubular Protection of Shenqi Fuzheng Injection in Treating Primar y Nephrot ic Syndrome

OBJECTIVE: To explore the effect and mechanism of Shenqi Fuzheng injection (SFI) on renal tubule in treating patients with primary nephrotic syndrome (PNS). METHODS: Eighty patients with PNS were randomly divided into two groups, 40 patients in the control group were treated by conventional therapy mainly with glucocorticoids; 40 patients in the treated group treated by conventional therapy plus intravenous injection of SFI additionally. The changes of serum albumin (sALB), urinary protein in 24 hrs (UP/24h), urinary levels of retinal binding protein (RBP), beta2 microglobulin (beta2-MG) and N-acetyl-D-glucosaminidase (NAG) as well as blood lipids before and after treatment were observed. RESULTS: After treatment, level of sALB increased and urinay levels of RBP, beta2-MG, NAG, UP/24h decreased in the treated group, as compared with those in the control group, showing significant difference (P < 0.05 or P < 0.01). Blood lipids level abated significantly after treatment in both groups (P < 0.01), comparison between them, levels of TC and LDL-C in the treated group were significantly lower than those in the control group (P < 0.01). CONCLUSION: SFI has protective effect on renal tubule in patients with PNS, also has effect on lowering blood lipids.