Elevated levels of CD4 antigen in sera of human immunodeficiency virus-infected populations. |
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| Authors: | M M Reddy M Vodian M H Grieco |
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| Affiliation: | R. A. Cooke Institute of Allergy, St. Luke's Roosevelt Hospital Center, New York, New York 10019. |
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| Abstract: | CD4 antigen levels in sera from asymptomatic intravenous drug users and homosexuals and patients with lymphadenopathy, acquired immunodeficiency syndrome-related complex, or acquired immunodeficiency syndrome were quantitated. Like soluble CD8, CD4 antigen levels were elevated in human immunodeficiency virus-seronegative asymptomatic intravenous drug users and homosexuals, probably reflecting infections such as cytomegalovirus, Epstein-Barr virus, and hepatitis B virus infections. The sera from human immunodeficiency virus-seropositive groups of patients with human immunodeficiency virus infection also had elevated levels of CD4 antigen, presumably reflecting infections like cytomegalovirus and human immunodeficiency virus infections. |
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