| 血管紧张素转换酶抑制剂治疗阿尔茨海默病的效果 |
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| 引用本文： | 储佺兵,苑瑞敏,童玉翠,陈广生,许家佳,张晗,孙永安.血管紧张素转换酶抑制剂治疗阿尔茨海默病的效果[J].江苏医药,2012,38(15):1800-1802. |
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| 作者姓名： | 储佺兵 苑瑞敏 童玉翠 陈广生 许家佳 张晗 孙永安 |
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| 作者单位： | 1. 马鞍山十七冶医院神经内科,安徽省,243000
2. 北京大学第一医院神经内科 |
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| 摘 要： | 目的观察血管紧张素转换酶抑制剂(ACEI)治疗阿尔茨海默病(AD)痴呆患者的精神行为症状、认知功能损害的效果。方法 52例AD痴呆患者口服盐酸卡托普利治疗12周,采用神经精神科问卷(NPI)评定患者的精神行为症状变化,采用简易智能状态检查量表评定患者的认知功能变化。结果治疗12周后,除情感淡漠外,NPI各项因子得分显著下降(P<0.05),NPI总分下降81.47%(P<0.05);照顾者的苦恼程度也随着患者精神行为症状的改善而降低;治疗前后患者的认知功能无显著性差异(P>0.05)。结论盐酸卡托普利可以明显改善AD痴呆患者的精神行为症状,但对患者的认知功能损害无明显疗效。
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| 关 键 词： | 阿尔茨海默病 血管紧张素转换酶抑制剂 |
Effects of angiotensin converting enzyme inhibitors on Alzheimer' s disease |
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| Institution: | CHU Quanbing,YUAN Ruimin,TONG Yucui,et al.Department of Neurology,Maanshan Hospital of MCC17,Maanshan 243000,CHINA |
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| Abstract: | Objective To observe the effects of hydrochloride captopril,one of angiotensin converting enzyme inhibitors(ACEIs),on behavioral and psychological symptoms and cognitive impairments of Alzheimer′s disease.Methods Fifty-two patients with Alzheimer′s disease were treated with captopril for 12 weeks.The neural psychiatric questionnaire(NPI) and the mini-mental state examination(MMSE) were used to evaluate the efficacy and cognitive changes.Results After treated for 12 weeks,the scores of each NPI factor were significantly decreased(P<0.05) and total scores of NPI decreased by 81.47%(P<0.05).The distress degrees of caregivers of patients decreased while the behavioral and psychological symptoms of patients improved.But the patients showed no cognitive benefits(P>0.05).Conclusion Hydrochloride captopril could significantly reduce the psychological and behavioral symptoms without improvement in the cognitive impairments. |
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| Keywords: | Alzheimer′s disease Angiotensin converting enzyme inhibitors |
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