| 星形胶质细胞上调基因-1蛋白在鼻咽癌中的表达及临床意义 |
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| 引用本文： | 李果 刘勇 徐芳 粟忠武 余长云 任舒灵 田勇泉 邱元正. 星形胶质细胞上调基因-1蛋白在鼻咽癌中的表达及临床意义[J]. 中国耳鼻咽喉颅底外科杂志, 2012, 18(5): 354-357 |
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| 作者姓名： | 李果 刘勇 徐芳 粟忠武 余长云 任舒灵 田勇泉 邱元正 |
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| 作者单位： | 中南大学湘雅医院耳鼻咽喉头颈外科,耳鼻咽喉重大疾病研究湖南省重点实验室,湖南长沙410008 |
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| 基金项目： | 国家自然科学基金面上项目（81202128,81172558）,高等学校博士学科点专项科研基金课题（20090162110065）,中南大学自由探索计划青年教师助推基金（2012QNZT099）. |
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| 摘 要： | 目的探讨星形胶质细胞上调基因-1(astrocyte elevated gene-1,AEG-1)蛋白在鼻咽癌中的表达及其临床意义。方法采用Western blotting技术检测AEG-1蛋白在4株鼻咽癌细胞株、47例鼻咽癌组织及21例鼻咽部黏膜中的表达。结果 AEG-1蛋白在鼻咽癌细胞和组织中的表达较鼻咽部黏膜均显著上调,其表达水平与患者血清EB病毒滴度的高低(P=0.046)、T分级(P=0.001)、临床分期(P=0.001)、颈部淋巴结转移(P=0.010)呈显著正相关。结论 AEG-1蛋白可能在鼻咽癌的发生发展中起重要作用。
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| 关 键 词： | 星形胶质细胞上调基因1 鼻咽癌 转移 蛋白印迹技术 |
Expression of AEG-1 protein in nasopharyngeal carcinoma and its clinical significance |
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| LI Guan,LIU Yong,XU Fang,SU Zhong-Wu,TU Chang-Yun,LIN Shu-Ling,TIAN Yong-Quan-??Qiu-Yuan-Zheng. Expression of AEG-1 protein in nasopharyngeal carcinoma and its clinical significance[J]. Chinese Journal of Otorhinolaryngology-skull Base Surgery, 2012, 18(5): 354-357 |
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| Authors: | LI Guan LIU Yong XU Fang SU Zhong-Wu TU Chang-Yun LIN Shu-Ling TIAN Yong-Quan-??Qiu-Yuan-Zheng |
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| Affiliation: | LI Guo, LIU Yong, XU Fang, et al. (Department of Otorhinolaryngology-Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha 410008, China) |
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| Abstract: | Objective To investigate the expression of AEG-1 protein and its clinical significance in nasopharyngeal carcinoma （NPC）. Methods Western blot was used for detecting the expression of AEG-1 protein in 4 NPC cell lines, 21 specimens of normal nasopharyngeal epithelium and 47 of NPC. Results The expression level of AEG-1 protein was significantly up-regulated in both NPC cell lines and NPC specimens. Moreover, the expression of AEG-1 protein was positively correlated to EB virus infection （ P = 0. 046 ） , T stage （ P = 0. 001 ） , clinical stage （ P = 0.001 ） and cervical lymph node metastasis （ P = 0.010 ）. Conclusion AEG-1 protein may olav a si~＇nificant role in the initiation and progression of NPC. |
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| Keywords: | AEG-1 Nasopharyngeal neoplasm Metastasis Western blot |
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