| Abstract: | A hundred and sixty-nine patients aged 51-80 years who had Stages I and II dyscirculatory encephalopathy were examined. A control group comprised 32 apparently healthy individuals of the same age. Cognitive disorders were rated using the mini-mental state examination (MMSE) scale. The serum activities of butyrylcholine esterase (BCE) and gamma-glutamyl transferase (gamma-GT) were studied. The development of moderate cognitive disorders was found to be accompanied by lower BCE and higher gamma-GT activities. The activity levels of these enzymes may be used as markers reflecting the cholinergic and glutamatergic neuromediatory systems involved in cognitive functions. |
