Abstract: | Analysis of 60 pituitary adenomas with acro-
megaly iiS made. All 60 surgical specimens are
studied by both light and electron microscopy.
By light microscopy we classified the adenomas
into strong acidophilic cell (16 cases) and weak
acidophilic cell (20 cases), stem cell (2 cases)
and mixed cell type adenomas (22 cases). By
electron micros.copy we classified them into
densely granulated (14 cases) and sparsely granu-
lated growth hormone (GH) cell adenomas (212
cases) in which there are fibrous bodies near
the indented part of the nucleus which are of
diagnostic value, corresponding to the round
lucent area near the indented nucleus seen by
light microscopy. The densely granulated and
sparsely granulated GH cells may coexist within
1 adenoma (4 cases). Some adenomas may con-
tain 2-3 kinds of secretory granules and are
called multiple functional adenomas, in this
series 18 had GH-;-PRL prolactin), 1 GH+ACTH
and l GH+PRL+ACTH. Strong acidophilic cells
correspond to densely granulated GH cells while
weak acidophilic celIs correspond to sparsely
granulated GH cells. The number of strong or
weak acidophilic cells and number of secretory
granules are not directly proportional to the GH
blood level. By electron microscopy GH, PRL
and ACTH secretory granules have characteristic
features which are not absolute. Correct diagnosis
is based upon combining the clinical symptoms
and signs, blood hormone levels and secretory
granule morphology. F'ibrous body diagnostic
value and their genesis and development are dis-
cussed. |