HYPERCALCAEMIA IN ASSOCIATION WITH RENAL FAILURE: THE ROLE OF IMMOBILISATION |
| |
| Authors: | R. L. PRINCE J. A. EISMAN R. W. SIMPSON |
| |
| Affiliation: | Lecturer in Medicine. University of Molbourne. Repatriation General Hospital. Heidelberg Victoria Currently. Senior Lecturer. Department of Medicine. Fromantic Hospital. WA;Head of the Bono and Mineral Research Section University Department of Medicine. Repatnation General Hospital Heidelberg Vic;The Medical Research Centre, Pance Henry's Hospital Melbourne, Vic |
| |
| Abstract: | Hypercalcaemia occurring after ten weeks of immobilisation was observed in four adult patients all of whom had had prior renal failure sufficient to require renal dialysis. In all patients parathyroid hormone levels were normal or low and in three plasma 1,25(OH)2D3 levels were low. These findings are consistent with immobilisation induced increases in bone calcium resorption. Renal excretion of calcium may have been impaired by renal dysfunction resulting in hypercalcaemia and suppression of plasma PTH and 1,25(OH)2D3 levels. Resolution of the hypercalcaemia was associated with remobilisation. Parathyroidectomy is inappropriate treatment. |
| |
| Keywords: | Hypercalcaemia renal failure immobilisation 1,25 dihydroxy vitamin D3 parathyroid hormone |
|
