维生素C和维生素E对糖尿病大鼠非酶糖化和过氧化反应的影响

以链脲佐菌素腹腔注射ＳＤ大鼠建立糖尿病动物模型，在纯营养素饲料配方中补充维生素Ｃ和／或维生素Ｅ，喂饲周，观察单独或联合补充维生素Ｃ、维生素Ｅ对糖尿病非酶糖化及过氧化的干预作用。结果显示维生素Ｃ和Ｅ联合补充可显著减少糖尿病大鼠血红蛋白、低「密度脂蛋白及肾脏皮质的糖化终产物（ＡＧＥｓ）含量，同时显著降低脂质过氧化产物丙二醛（ＭＤＡ）水平，单独补充维生素Ｃ或维生素Ｅ能显著降低糖尿病鼠血清及肾脏ＭＤＡ含量

Effects of vitamin E and vitamin C on nonenzymatic glycation and peroxidation in experimental diabetic rats

SD rats were peritoneally injected with streptozotocin (STZ) to establish diabetic animal model.The changes of nonenzymatic glycation and peroxidation in rats supplemented with vitamin C and/ or vitamin E during five weeks were investigated.It was found that the glycated hemoglobin,glycated L DL, renal cortical AGEs and MDA in sera and renal cortex significantly decreased after supplementation of vitamins E and C jointly.It was also observed that the MDA in serum and the cortex of kidney but not glycated hemoglobin,glycated L DL and AGEs significantly decreased in the groups supplemented with vitamin C or vitamin E separately.The results suggested that jointsupplementation of vitamin C and vitamin E could inhibit nonenzym atic glycation obviously and peroxidation in diabetic rats and protect the kidney from damage under hyperglycem ia.