Effect of semax and semax-heparin mixture on isolated heart activity after total ischemia in rats |
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| Authors: | A V Orlov A E Khomutov I V Mukhina Yu B Zimin S B Parin D V Kozin |
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| Institution: | (1) Department of Human and Animals Physiology, N. I. Labachevskii State, University, Nizhnii Novgorod, USSR;(2) Central Research Laboratory, Nizhnii Novgorod State Medical Academy, Nizhnii Novgorod, USSR |
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| Abstract: | Semax administered after 40-min total ischemia of isolated heart improved the recovery of heart rate and reduced myocardial
contracture. When administered prior to ischemia, Semax exerted a negative effect on recovery of heart contractility. Semax-heparin
mixture significantly improved the recovery of cardiac indices (end-diastolic pressure, heart rate, and relaxation rate) irrespective
of administration schedule.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 128, No. 11, pp. 494–496, November, 1999 |
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| Keywords: | Semax heparin isolated heart ischemia reperfusion |
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