| 角化生长因子在慢性肺疾病早产大鼠的表达 |
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| 引用本文： | 李冬梅,张宏伟,薛辛东,岳志军,南春红,闫丽娟.角化生长因子在慢性肺疾病早产大鼠的表达[J].中国优生与遗传杂志,2005,13(6):11-13. |
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| 作者姓名： | 李冬梅 张宏伟 薛辛东 岳志军 南春红 闫丽娟 |
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| 作者单位： | 1. 中国医科大学附属第二医院儿科,辽宁,沈阳,110004
2. 辽宁中医学院附属医院儿科,辽宁,沈阳,110032 |
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| 摘 要： | 目的探讨高氧致CLD早产大鼠KGF表达的变化规律.方法 60只新生早产大鼠随机分为2组,每组30只:A组-对照组;B组-高氧组(吸入95%O2).分别采用Western Blotting及RT-PCR检测肺组织KGF及其mRNA表达.结果高氧组肺内KGF及其mRNA表达高于对照组.结论高氧引起新生早产大鼠肺内KGF及其mRNA的表达随时间发生变化.
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| 关 键 词： | 慢性肺疾病 角化生长因子 早产大鼠 |
| 文章编号： | 1006-9534(2005)06-0011-03 |
| 修稿时间： | 2004年12月14 |
Expression of keratimocyte growth factor in premature rats with hyperoxia-induced chronic lung disease |
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| LI Dong-mei,ZHANG Hong-wei,XUE Xin-dong,YUE Zhi-jun,NAN Chun-hong,YAN Li-juan.Expression of keratimocyte growth factor in premature rats with hyperoxia-induced chronic lung disease[J].Chinese Journal of Birth Health & Heredity,2005,13(6):11-13. |
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| Authors: | LI Dong-mei ZHANG Hong-wei XUE Xin-dong YUE Zhi-jun NAN Chun-hong YAN Li-juan |
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| Abstract: | Objective: To demonstrate changes of KGF in premature rats with hyperoxia-induced CLD. Methods: Neonatal premature rats were divided into two groups(30 for each) at random: group A-controlled; groupB- exposed to 95% O_2.Expressions of KGF and its mRNA were determined with Western Blotting and RT-PCR respectively. Results: Exposed to 95% O_2, expressions of KGF and its mRNA are higher than controlled group. Conclusion:Hyperoxia has a significant effect on changes of KGF and its mRNA over time. |
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| Keywords: | Chronic lung disease Keratimocyte growth factor Rat |
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