| CD_(44)v_6与肿瘤侵袭和转移研究进展 |
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| 引用本文： | 张秀亮,朱志图,哈敏文. CD_(44)v_6与肿瘤侵袭和转移研究进展[J]. 医学综述, 2008, 14(8): 1162-1165 |
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| 作者姓名： | 张秀亮 朱志图 哈敏文 |
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| 作者单位： | 辽宁医学院病附属第一医院肿瘤科,辽宁,锦州,121001 |
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| 摘 要： | CD44是由单一基因所编码的具有高度异质性的单链膜表面糖蛋白家族,介导细胞与细胞、细胞与细胞外基质之间的黏附作用,其拼接变异体的不同构成了其基因产物的多样性;尤其拼接变异体V6(CD44v6)被认为具有致瘤性;CD44v6在一定程度上参与了肿瘤的发生发展,是预后因子之一,并且可能作为肿瘤进展的标志物。CD44v6的过表达与肿瘤的侵袭、转移和临床分期有关。对CD44v6的检测不仅能预测患者的预后,而且还可为肿瘤的个体化治疗直接提供信息。
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| 关 键 词： | CD_(44)v_6 肿瘤侵袭和转移 单克隆抗体 分子靶向治疗 |
| 文章编号： | 1006-2084(2008)08-1162-04 |
| 修稿时间： | 2007-10-22 |
Progress Relationship of CD_(44)v_6 with Invasion and Metastasis of Tumor |
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| ZHANG Xiu-liang,ZHU Zhi-tu,HA Min-wen. Progress Relationship of CD_(44)v_6 with Invasion and Metastasis of Tumor[J]. Medical Recapitulate, 2008, 14(8): 1162-1165 |
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| Authors: | ZHANG Xiu-liang ZHU Zhi-tu HA Min-wen |
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| Affiliation: | Department of oncology;First Affiliated Hopspital of Liaoning Medical College;Jinzhou;121001 |
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| Abstract: | CD44 is a single strand glucoprotein family encoded by single gene on the memebrane surface with high heterology,which can mediate adhesion between cell and cell as well as cell and extracellular matrix.Its different splicing variants will result in the variety of its gene products.Especially,its splicing varant V6(CD_(44)v_6)is condided to have oncogenicity.CD_(44)v_6 takes part in the genesis and development of tumor at some certain and is one of prognostic factors.So it will be the marker indicating tumo... |
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| Keywords: | CD44v6 Invasion and metastasis of tumor Moneclonal antibody Targeted molecular therapy |
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